Henry R. Kranzler
University of Pennsylvania
692 Papers
5.7K Citations
Henry R. Kranzler is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Alcohol dependence & Medicine. The author has an hindex of 97, co-authored 623 publications. Previous affiliations of Henry R. Kranzler include Medical University of South Carolina & United States Department of Veterans Affairs.
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Papers
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
Nathan C. Gaddis,Ravi Mathur,Jesse Marks,Linran Zhou,Bryan C. Quach,Alex Waldrop,Orna Levran,Arpana Agrawal,Matthew Randesi,Miriam Adelson,Paul W. Jeffries,Emma C. Johnson,Nicholas G. Martin,Louisa Degenhardt,Grant W. Montgomery,Leah Wetherill,Dongbing Lai,Kathleen K. Bucholz,Tatiana Foroud,Bernice Porjesz,Bradley Todd Webb,Richard C. Crist,Henry R. Kranzler,Hang Zhou,Gary K. Hulse,Dieter B. Wildenauer,Erin Kelty,John Attia,Elizabeth G. Holliday,Mark McEvoy,Rodney J. Scott,Sibylle G. Schwab,Brion S. Maher,Richard Gruza,Mary Jeanne Kreek,Elliot C. Nelson,Wade H Berrettini,Joel Gelernter,Howard J. Edenberg,Laura J. Bierut,Dana B. Hancock,Eric O. Johnson +41 more
TL;DR: The authors applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction Consortium (GENOA) data and published studies (Psychiatric Genomics Consortium, Million Veteran Program, and Partners Health), comprising 23,367 cases and effective sample size of 88,114 individuals of European ancestry.
Trauma and posttraumatic stress interact with sex-specific risk loci for suicidality and converge on brain extracellular matrix biology and synaptic plasticity
Frank R. Wendt,Gita A. Pathak,Daniel F. Levey,Yaira Z. Nunez,Cassie Overstreet,Chelsea Tyrrell,Keyrun Adhikari,Flavio De Angelis,Daniel S. Tylee,Aranyak Goswami,John H. Krystal,Chadi G. Abdallah,Murray B. Stein,Murray B. Stein,Henry R. Kranzler,Henry R. Kranzler,Joel Gelernter,Renato Polimanti +17 more
TL;DR: A multivariate gene-by-environment genome-wide interaction study of suicidality in 123,633 individuals using a covariance matrix based on 26 environments related to traumatic experiences, posttraumatic stress, social support, and socioeconomic status discovered sex-specific risk loci exhibiting interaction effects driven by PTSD.
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Topiramate Versus Naltrexone for Alcohol Use Disorder: A Genotype-Stratified Double-Blind Randomized Controlled Trial.
Kirsten C Morley,Henry R. Kranzler,Natasha Luquin,Nazila Jamshidi,Claire Adams,Mark Montebello,Christopher Tremonti,Gezelle Dali,Warren Logge,Andrew Baillie,M. Teesson,Ronald Trent,Paul Haber +12 more
TL;DR: This genotype-stratified RCT compares topiramate and naltrexone for alcohol use disorder, finding topiramate non-inferior to naltrexone in reducing heavy drinking days and superior in reducing BMI, craving, and liver injury markers.
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Post‐treatment effects of topiramate on alcohol‐related outcomes: A combined analysis of two placebo‐controlled trials
Henry R. Kranzler,Richard S. Finn,Timothy Pond,Emily E. Hartwell,Joel Gelernter,Richard C. Crist,Katie Witkiewitz +6 more
TL;DR: The robust effects of topiramate on alcohol‐related outcomes during treatment diminish substantially once the medication is discontinued and the overall multivariate medication effects on outcomes during 3‐ and 6‐month follow‐up were not significant.
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Genome-wide association study of stimulant dependence.
Jiayi Wu Cox,Richard Sherva,Leah Wetherill,Tatiana Foroud,Howard J. Edenberg,Henry R. Kranzler,Joel Gelernter,Lindsay A. Farrer +7 more
TL;DR: A genome-wide association study for stimulant dependence was performed in a discovery cohort of African- (AA) and European-ancestry (EA) subjects ascertained for genetic studies of alcohol, opioid, and cocaine use disorders as discussed by the authors.