Henry Pratt

TL;DR: A Benchmark of candidate Enhancer-Gene Interactions (BENGI) is developed by integrating the recently developed Registry of cCREs with experimentally derived genomic interactions to test several published computational methods for linking enhancers with genes, including signal correlation and the TargetFinder and PEP supervised learning methods.

TL;DR: The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD proteins as discussed by the authors, and they stimulate transcriptional activation by AP-1 proteins.

TL;DR: The authors of as discussed by the authors examined transposable element (TE) content of 248 mammalian genome assemblies and found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE accumulation.

TL;DR: In this paper , the evolutionary trajectories for 0.92 million human candidate cis-regulatory elements (cCREs) and 15.6 million human transcription factor binding sites (TFBSs) were charted using reference-free alignment across 241 mammalian genomes produced by the Zoonomia Consortium.