Henry Koo
ImClone Systems
7 Papers
49 Citations
Henry Koo is an academic researcher from ImClone Systems. The author has contributed to research in topics: Growth factor receptor & Protein kinase B. The author has an hindex of 6, co-authored 7 publications.
Chat about Author
Papers
•Journal Article
A Fully Human Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor Blocks Ligand-Dependent Signaling and Inhibits Human Tumor Growth in Vivo
Douglas Burtrum,Zhenping Zhu,Dan Lu,Donna Marie Anderson,Marie Prewett,Daniel S. Pereira,Rajiv Bassi,Rashed Abdullah,Andrea T. Hooper,Henry Koo,Xenia Jimenez,Danielle P. Johnson,Robin Apblett,Paul Kussie,Peter Bohlen,Larry Witte,Daniel J. Hicklin,Dale L. Ludwig +17 more
TL;DR: Results demonstrate that A12 possesses strong antitumor activity in vitro and in vivo and may therefore be an effective therapeutic candidate for the treatment of cancers that are dependent on IGF-IR signaling for growth and survival.
A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity
Dan Lu,Haifan Zhang,Henry Koo,James R. Tonra,Paul Balderes,Marie Prewett,Eric Corcoran,Venkata R.M. Mangalampalli,Rajiv Bassi,Deborah Anselma,Dipa Patel,Xiaoqiang Kang,Dale L. Ludwig,Daniel J. Hicklin,Peter Bohlen,Larry Witte,Zhenping Zhu +16 more
TL;DR: A recombinant human IgG-like bispecific antibody, a Di-diabody, produced using the variable regions from two antagonistic antibodies that binds to both EGFR and IGFR and effectively blocked both EGF- and IGF-stimulated receptor activation and tumor cell proliferation.
310
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity.
Zhenping Zhu,Koichi Hattori,Haifan Zhang,Xenia Jimenez,Dale L. Ludwig,Sergio Dias,Paul Kussie,Henry Koo,H J Kim,Dan Lu,Meilin Liu,Rafael Tejada,Matthias Friedrich,Peter Bohlen,Larry Witte,Shahin Rafii +15 more
TL;DR: Two fully human anti-KDR antibodies are produced, from Fab fragments originally isolated from a large antibody phage display library, that strongly inhibited VEGF-induced migration of human leukemia cells in vitro, and when administered in vivo, significantly prolonged survival of NOD-SCID mice inoculated withhuman leukemia cells.
226
Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer
Yan Wu,Zhaojing Zhong,James Huber,Rajiv Bassi,Bridget Finnerty,Erik Corcoran,Huiling Li,Elizabeth Navarro,Paul Balderes,Xenia Jimenez,Henry Koo,Venkata R.M. Mangalampalli,Dale L. Ludwig,James R. Tonra,Daniel J. Hicklin +14 more
TL;DR: IMC-18F1 anti-VEGFR-1 has potential to provide clinical benefit to cancer patients and was evaluated in human breast cancer xenograft models and enhanced the antitumor efficacy of cytotoxic agents commonly used to treat breast cancer.
147
Cloning, expression, and purification of mouse heparanase.
Hua-Quan Miao,Elizabeth Navarro,Sheetal Patel,David Sargent,Henry Koo,Hong Wan,Anadellys Plata,Qinwei Zhou,Dale L. Ludwig,Peter Bohlen,Paul Kussie +10 more
TL;DR: The full-length mouse gene was cloned from a mouse embryo cDNA library and determined to encode a protein of 535 amino acids that is 77% identical to human heparanase, which is an endoglucuronidase that plays an important role in tumor invasion and metastasis.
40