Henry Keijzer
8 Papers
10 Citations
Henry Keijzer is an academic researcher. The author has contributed to research in topics: Melatonin & Circadian rhythm. The author has an hindex of 6, co-authored 8 publications.
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Papers
Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders
TL;DR: Knowing the patient's individual circadian timing by assessing DLMO can improve diagnosis and treatment of CRSD with melatonin as well as other therapies such as light or chronotherapy, and optimizing treatment timing will shorten the time required to achieve results.
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CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?
Wiebe Braam,Henry Keijzer,H. A. J. Struijker Boudier,Robert Didden,Martijn Smits,Leopold M. G. Curfs +5 more
TL;DR: DNA extracted from saliva samples of 15 consecutive patients with disappearing effectiveness of melatonin found a single nucleotide polymorphism (SNP) of CYP1A2 of autism spectrum disorder may give a new direction for research into the genetic background of autism.
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Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep–wake rhythm disorders
Henry Keijzer,Marcel G. Smits,Twan Peeters,Caspar W. N. Looman,Silvia C. Endenburg,Jacqueline M.T. Klein Gunnewiek +5 more
TL;DR: DLMO can be reliably measured in saliva that is conveniently collected at home and correlates moderately with sleep onset, and significantly differed between different age groups and increased with age.
67
Precision medicine in circadian rhythm sleep-wake disorders : current state and future perspectives
Henry Keijzer,Mark A. Snitselaar,Marcel G. Smits,Karen Spruyt,Karen Spruyt,Phyllis C. Zee,Friederike Ehrhart,Leopold M. G. Curfs +7 more
TL;DR: Routinely measuring treatment results using patient-reported outcome measures and clinical neurophysiological instruments will boost precision sleep medicine.
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Automated genomic DNA extraction from saliva using the QIAxtractor.
TL;DR: DNA can be extracted in sufficient amounts from Salivette® with a fully automated system with a short turnaround time and real-time PCR can be performed with these samples.
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