Henning Wackerhage
University of Dundee
9 Papers
47 Citations
Henning Wackerhage is an academic researcher from University of Dundee. The author has contributed to research in topics: Skeletal muscle & Muscle hypertrophy. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Henning Wackerhage include University of Nottingham.
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Papers
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Daniel J. Cuthbertson,Kenneth Smith,Kenneth Smith,John A. Babraj,Graham P. Leese,T Waddell,Philip J. Atherton,Philip J. Atherton,Henning Wackerhage,Peter M. Taylor,M. J. Rennie,M. J. Rennie +11 more
TL;DR: It is demonstrated that EAA stimulate MPS independently of increased insulin availability, and in the elderly, a deficit in MPS in the basal state is unlikely; and the decreased sensitivity and responsiveness of MPS to EAA, associated with decrements in the expression and activation of components of anabolic signaling pathways, are probably major contributors to the failure of muscle maintenance inThe elderly.
1.2K
Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
Philip J. Atherton,Philip J. Atherton,Philip J. Atherton,John A. Babraj,Kenneth Smith,Jaipaul Singh,Michael J. Rennie,Henning Wackerhage +7 more
TL;DR: The data suggest that a specific signaling response to LFS is a specific activation of the AMPK‐PGC‐1α signaling pathway which may explain some endurance training adaptations.
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Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes.
E Cummings,Harinder S. Hundal,Henning Wackerhage,M Hope,Mino D. C. Belle,Ernest Adeghate,Jaipaul Singh +6 more
TL;DR: The results indicate that M. charantia fruit juice acts like insulin to exert its hypoglycaemic effect and moreover, it can stimulate amino acid uptake into skeletal muscle cells just like insulin.
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Concentrations of signal transduction proteins exercise and insulin responses in rat extensor digitorum longus and soleus muscles.
TL;DR: The experiments show that signal transduction protein concentrations vary between fast and slow muscles, presumably reflecting a concentration difference on a fibre level.
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Myostatin and NF-κB Regulate Skeletal Myogenesis Through Distinct Signaling Pathways
TL;DR: Findings highlight the distinctive differences by which Mstn and NF-κB signal to regulate myogenesis, a finding which broadens the understanding of how these pathways function in both development and disease.
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