Henner Friedle
University of Ulm
5 Papers
43 Citations
Henner Friedle is an academic researcher from University of Ulm. The author has contributed to research in topics: Response element & Transcription factor. The author has an hindex of 5, co-authored 5 publications.
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Papers
Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1.
TL;DR: Evidence that Xvent- 2B (Xvent-2) maintains its own expression through autoregulation is provided, and glutathioneS-transferase pull-down experiments demonstrated that X vent-2B directly and specifically interacts with Smad1.
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Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.
TL;DR: The temporal activation and the spatial restriction of XFD‐1′ gene activity to the Spemann organizer is regulated by antagonistic actions of two distinct members of the TGF‐beta family (activin and BMP) which act on different promoter elements.
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Transcriptional regulation of Xvent homeobox genes
TL;DR: Xvent-2B by itself is not sufficient to activate transcription of the Xvent-1B gene, but that there is a requirement for additional factor(s) being synthesized after midblastula transition, which suggests that this gene is a direct target of BMP-signalling.
Cooperative Interaction of Xvent-2 and GATA-2 in the Activation of the Ventral Homeobox Gene Xvent-1B
Henner Friedle,Walter Knöchel +1 more
TL;DR: This study reports on the cooperative effect of Xvent-2 and the zinc finger transcription factor GATA-2 on the promoter of theXvent-1B gene, and shows that Gata-2 is a direct target gene of bone morphogenetic protein-4 and that GATA
Xvent‐1 mediates BMP‐4‐induced suppression of the dorsal‐lip‐specific early response gene XFD‐1′ in Xenopus embryos
TL;DR: Biological and molecular data suggest that Xvent‐1 acts as direct repressor for XFD‐1′ transcription and mediates BMP‐4‐induced inhibition, and is mediated by Xvent homeobox proteins.