Hellen A. M. Bakker
Leiden University
6 Papers
Hellen A. M. Bakker is an academic researcher from Leiden University. The author has contributed to research in topics: Cell adhesion molecule & Cell adhesion. The author has an hindex of 6, co-authored 6 publications.
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Papers
Ep-CAM : a human epithelial antigen is a homophilic cell-cell adhesion molecule
TL;DR: It is demonstrated here that EGP40 is an epithelium-specific intercellular adhesion molecule that resembles to some extent the molecules of the immunoglobulin superfamily of cell adhesion molecules (CAMs), although no immunoglobeulin-like repeats are present in the EGP30 molecule.
Epithelial Cell Adhesion Molecule (Ep-CAM) Modulates Cell–Cell Interactions Mediated by Classic Cadherins
Sergey V. Litvinov,Maarten Balzar,Manon J. Winter,Hellen A. M. Bakker,Inge H. Briaire-de Bruijn,Frans J. Prins,Gert Jan Fleuren,Sven O. Warnaar +7 more
TL;DR: The ability of Ep-CAM to modulate the cadherin-mediated cell–cell interactions, as demonstrated in the present study, suggests a role for this molecule in development of the proliferative, and probably malignant, phenotype of epithelial cells.
331
•Journal Article
Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation.
Sergey V. Litvinov,W.J. van Driel,C. M. Van Rhijn,Hellen A. M. Bakker,H. Van Krieken,Gert Jan Fleuren,Sven O. Warnaar +6 more
TL;DR: It is demonstrated that the expression of Ep-CAM in cervical squamous epithelium is associated with abnormal proliferation of cell populations that are not committed to terminal differentiation.
172
Evidence for a Role of the Epithelial Glycoprotein 40 (Ep-CAM) in Epithelial Cell-Cell Adhesion
Sergey V. Litvinov,Hellen A. M. Bakker,Maia M. Gourevitch,Markwin P. Velders,Sven O. Warnaar +4 more
TL;DR: The data presented demonstrate that the Ep-CAM molecules are functionally active in the epithelial and carcinoma cells tested, are capable of mediating Ca(++)-independent intercellular adhesions, and are not likely to be involved in cell-substrate adhesion.
144
Cytoplasmic Tail Regulates the Intercellular Adhesion Function of the Epithelial Cell Adhesion Molecule
Maarten Balzar,Hellen A. M. Bakker,Inge H. Briaire-de-Bruijn,Gert Jan Fleuren,Sven O. Warnaar,Sergey V. Litvinov +5 more
TL;DR: The results demonstrate that the cytoplasmic domain of Ep-CAM regulates the adhesion function of the molecule through interaction with the actin cytoskeleton via α-actinin.