Hélène Faure
Centre national de la recherche scientifique
54 Papers
235 Citations
Hélène Faure is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Smoothened & Sonic hedgehog. The author has an hindex of 25, co-authored 51 publications.
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Papers
Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system
Elisabeth Traiffort,Dorota Charytoniuk,Laurent Watroba,Hélène Faure,Nicole Sales,Martial Ruat +5 more
TL;DR: The expression pattern of these three genes as well as of Gli1, and their developmental regulation in the cerebellum, suggest a possible role for Hedgehog signalling in the control of various cell populations within the cere Bellum, particularly in granule cell proliferation and/or differentiation that might be impaired in proliferative states such as medulloblastomas.
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In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor.
TL;DR: The extracellular calcium-sensing receptor (CaSR) is activated by divalent cations and might mediate some of the effects of strontium ranelate, a new drug for the prevention and treatment of post-menopausal osteoporosis, to contribute to its reported antiosteoporotic effects.
145
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
TL;DR: It is shown that radiolabelled SHHN peptides are synthesized in the adult hamster retina and are transported axonally along the optic nerve to the superior colliculus in vivo and suggested that the roles of this extracellular protein are more diverse than originally thought.
111
Functional Characterization of Sonic Hedgehog Mutations Associated with Holoprosencephaly
Elisabeth Traiffort,Christèle Dubourg,Hélène Faure,Didier Rognan,Sylvie Odent,Marie-Renée Durou,Véronique David,Martial Ruat +7 more
TL;DR: This work demonstrates that most of the HPE-associated SHH mutations analyzed have a deleterious effect on the availability of SHH-N and its biological activity, and suggests that other factors intervene in the development of the spectrum of HPE anomalies.
97
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
Antonio Solinas,Hélène Faure,Hermine Roudaut,Elisabeth Traiffort,Angèle Schoenfelder,André Mann,Fabrizio Manetti,Maurizio Taddei,Martial Ruat +8 more
TL;DR: Findings suggest that original molecules prepared by ligand-based structural optimization will help delineate Smo and Hh functions and can be developed as potential anticancer agents.
96