Helen Remotti

TL;DR: Compared with the wild type, mouse embryonic fibroblasts derived from chop -/- animals exhibited significantly less programmed cell death when challenged with agents that perturb ER function, and the proximal tubule epithelium of chop -/+ animals exhibited fourfold lower levels of TUNEL-positive cells, and significantly less evidence for subsequent regeneration.

TL;DR: It is concluded that gastrointestinal stromal tumors show striking morphological and immunophenotypic similarities with ICC and that they may originate from stem cells that differentiate toward a pacemaker cell phenotype and it is proposed that the noncommittal name "gastrointestinal stromic tumor" be replaced by gastrointestinal pacemaker Cell tumor.

TL;DR: Key elements of the consensus are the defining role of KIT immunopositivity indiagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term benign for any GIST, at least at the present time.

TL;DR: An intestinal DCLK1⁺ tuft cell population is defined that is long lived, quiescent, and important for intestinal homeostasis and regeneration, but are activated by tissue injury and can serve to initiate colon cancer.