Helén Nilsson
Lund University
27 Papers
190 Citations
Helén Nilsson is an academic researcher from Lund University. The author has contributed to research in topics: Neuroblastoma & Biology. The author has an hindex of 15, co-authored 25 publications. Previous affiliations of Helén Nilsson include Karolinska Institutet.
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Papers
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier,Erik Fredlund,Tobias Löfstedt,Rosa Noguera,Samuel Navarro,Helén Nilsson,Alexander Pietras,Johan Vallon-Christersson,Åke Borg,Katarina Gradin,Lorenz Poellinger,Sven Påhlman +11 more
TL;DR: High HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material and have general tumor biological implications.
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Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
Annika Jögi,Ingrid Øra,Helén Nilsson,Åsa Lindeheim,Yuichi Makino,Lorenz Poellinger,Håkan Axelson,Sven Påhlman +7 more
TL;DR: The findings suggest a novel mechanism for selection of highly malignant tumor cells with stem-cell characteristics, and hypoxia apparently causes dedifferentiation both in vitro and in vivo.
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Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes
David Lindgren,Pontus Eriksson,Krzysztof M. Krawczyk,Helén Nilsson,Jennifer Hansson,Srinivas Veerla,Jonas Sjölund,Mattias Höglund,Martin Johansson,Håkan Axelson +9 more
TL;DR: In this study, in-depth analyses of normal kidney tissue transcriptomes from the TCGA are performed and it is demonstrated that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between samples.
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Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate
Helén Nilsson,David Lindgren,A Mandahl Forsberg,Hindrik Mulder,Håkan Axelson,Martin Johansson +5 more
TL;DR: A strikingly reduced mitochondrial respiratory capacity of primary human ccRCC cells is shown, resulting in enhanced sensitivity to glycolytic inhibition by 3-Bromopyruvate (3BrPA), a finding that highlights the importance of using biologically relevant models in the search for new candidate cancer therapies.
•Journal Article
Staphylococcal enterotoxin d is a promiscuous superantigen offering multiple modes of interactions with the mhc class ii receptors
Reem Al-Daccak,Khalil Mehindate,Farida Damdoumi,Pierre Étongué-Mayer,Helén Nilsson,Per Antonsson,Michael Sundström,Mikael Dohlsten,Rafick-Pierre Sekaly,Walid Mourad +9 more
TL;DR: Dimerization of MHC class II molecules on the cell surface of human THP-1 monocytic cell line is a requirement for staphylococcal superantigen (SAG)-induced cytokine gene expression and these various modes of SED binding may be used to preserve bivalency regardless of variability in the MHCclass II alpha/beta/peptide complexes.
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