Helen L. Williams
University of Manchester
24 Papers
116 Citations
Helen L. Williams is an academic researcher from University of Manchester. The author has contributed to research in topics: Recall & Biology. The author has an hindex of 10, co-authored 22 publications. Previous affiliations of Helen L. Williams include University of Leeds & University of Richmond.
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Papers
Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair.
Laura Campbell,Elaine Emmerson,Helen L. Williams,Charis R Saville,Andrée Krust,Pierre Chambon,Kimberly A. Mace,Matthew J. Hardman +7 more
TL;DR: It is revealed that inflammatory cell-expressed ERα promotes alternative macrophage polarization, which is beneficial for timely healing, and will likely be of relevance to many pathologies involving excessive inflammation.
124
Staphylococcus aureus Second Immunoglobulin-Binding Protein drives atopic dermatitis via IL-33
Arwa Al Kindi,Helen L. Williams,Kenshiro Matsuda,Abdullah M. Alkahtani,Charis R Saville,Hayley M. Bennett,Yasmine Alshammari,Soo Yee Tan,Catherine A. O'Neill,Akane Tanaka,Hiroshi Matsuda,Peter D. Arkwright,Joanne L. Pennock +12 more
TL;DR: It is shown that IL-33 was essential in inducing the immune response to S. aureus in vivo, and the Second Immunoglobulin-Binding Protein (Sbi) is a unique type 2-promoting virulence factor capable of initiating the type-2 promoting cytokine activity underlying AD.
Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response
Craig McKibbin,Alina Mares,Michela Piacenti,Helen L. Williams,Peristera Roboti,Marjo Puumalainen,Anna C. Callan,Karolina Lesiak-Mieczkowska,Stig Linder,Hanna Harant,Stephen High,Sabine L. Flitsch,Roger C. Whitehead,Eileithyia Swanton +13 more
TL;DR: The results suggest that the accumulation of non-translocated proteins in the cytosol may represent a novel mechanism that contributes to UPR activation, and indeed this can be recapitulated with an alternative and quite distinct inhibitor of ER translocation.
Recollection in adolescents with Autism Spectrum Disorder
TL;DR: These findings point to a specific and subtle recollection impairment in adolescents with ASD, at least when subjective methods are used, and how these might relate to differences in the self and to the brain abnormalities in ASD is discussed.
35
Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways
Mina Olga Aletrari,Craig McKibbin,Helen L. Williams,Vidya Pawar,Paola Pietroni,J. Michael Lord,Sabine L. Flitsch,Roger C. Whitehead,Eileithyia Swanton,Stephen High,Robert A. Spooner +10 more
TL;DR: It is found that for SLTx, ESI treatment of cells was protective by reducing the rate of toxin delivery to the ER, and ESI acts on one or more components that function during vesicular transport, whilst at least one retrograde trafficking pathway, that of ricin, remains unperturbed.