Heinrich Sticht
University of Erlangen-Nuremberg
347 Papers
2.2K Citations
Heinrich Sticht is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 55, co-authored 311 publications. Previous affiliations of Heinrich Sticht include University of Bayreuth.
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Papers
De novo variants in snap25 cause an early-onset developmental and epileptic encephalopathy
Chiara Klöckner,Heinrich Sticht,Pia Zacher,Bernt Popp,Holly E. Babcock,Dewi P. Bakker,Katy Barwick,Michaela Bonfert,Carsten G. Bönnemann,Eva H. Brilstra,Wendy K. Chung,Angus John Clarke,Patrick Devine,Sandra Donkervoort,Jamie L. Fraser,Jennifer Friedman,Jennifer Friedman,Alyssa Gates,Jamal Ghoumid,Emma Hobson,Gabriella Horvath,Jennifer Keller-Ramey,Boris Keren,Manju A. Kurian,Virgina Lee,Kathleen A. Leppig,Johan Lundgren,Marie T. McDonald,Amy McTague,Heather C Mefford,Cyril Mignot,Mohamad A. Mikati,Caroline Nava,F. Lucy Raymond,F. Lucy Raymond,Julian R. Sampson,Alba Sanchis-Juan,Alba Sanchis-Juan,Vandana Shashi,Joseph T. Shieh,Marwan Shinawi,Anne Slavotinek,Tommy Stödberg,Nicholas Stong,Jennifer A. Sullivan,Ashley C. Taylor,Tomi L. Toler,Marie-José H. van den Boogaard,Saskia N. van der Crabben,Koen L.I. van Gassen,Richard H. van Jaarsveld,Jessica Van Ziffle,Alexandrea Wadley,Matias Wagner,Kristen Wigby,Saskia B. Wortmann,Saskia B. Wortmann,Yuri A. Zarate,Rikke S. Møller,Johannes R. Lemke,Konrad Platzer +60 more
TL;DR: Findings advance the concept of a group of neurodevelopmental disorders that may be termed "SNAREopathies" with intellectual disability and early-onset epilepsy mostly occurring before the age of two years.
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HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop
Kristin Eissmann,Sebastian Mueller,Heinrich Sticht,Susan Jung,Peng Zou,Shibo Jiang,Shibo Jiang,Andrea Gross,Jutta Eichler,Bernhard Fleckenstein,Heide Reil +10 more
TL;DR: The results of the present study provide initial proof of concept that peptides targeted to the gp41 disulfide loop are able to inhibit HIV fusion and should inspire the development of this new class of HIV-1 entry inhibitors.
Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability
Lars Björn Riecken,Hasan Tawamie,Carsten Dornblut,Rebecca Buchert,Amina Ismayel,Alexander Schulz,Johannes Schumacher,Heinrich Sticht,Katja J. Pohl,Yan Cui,André Reis,Helen Morrison,Rami Abou Jamra +12 more
TL;DR: Functional analysis revealed that the altered ezrin protein is no longer able to bind Ras and facilitate its activation, thus revealing a possible mechanism for its phenotype in humans.
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Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
Mirjam Steingruber,Lena Keller,Eileen Socher,Sabrina Ferré,Anne-Marie Hesse,Yohann Couté,Friedrich Hahn,Nicole Büscher,Bodo Plachter,Heinrich Sticht,Manfred Marschall +10 more
TL;DR: The findings unravel a number of cyclin type–specific differences in pUL97 interactions and suggest a multifaceted regulatory impact of cyclins on HCMV replication.
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CD83 and GRASP55 interact in human dendritic cells.
Marcello F. Stein,Katja Blume,Christiane Silke Heilingloh,Mirko Kummer,Brigitte Biesinger,Heinrich Sticht,Alexander Steinkasserer +6 more
TL;DR: It is shown for the first time that GRASP55 interacts with CD83 shortly after induction of DC maturation and that this interaction plays a role in CD83 glycosylation as well as in surface expression of CD83 on DCs.
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