Heino Velazquez
Yale University
68 Papers
196 Citations
Heino Velazquez is an academic researcher from Yale University. The author has contributed to research in topics: Distal convoluted tubule & Renalase. The author has an hindex of 34, co-authored 68 publications. Previous affiliations of Heino Velazquez include Lund University & Veterans Health Administration.
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Papers
Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption
David B. Simon,Yin Lu,Yin Lu,Keith A. Choate,Keith A. Choate,Heino Velazquez,Essam Al-Sabban,Manuel Praga,Giorgio Casari,Alberto Bettinelli,Giacomo Colussi,Juan Rodriguez-Soriano,David A. McCredie,David V. Milford,Sami A. Sanjad,Richard P. Lifton,Richard P. Lifton +16 more
TL;DR: Insight is provided into Mg2+ homeostasis, the role of a tight junction protein in human disease is demonstrated, and an essential component of a selective paracellular conductance is identified.
1.1K
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Jianchao Xu,Guoyong Li,Peili Wang,Heino Velazquez,Xiaoqiang Yao,Yanyan Li,Yanling Wu,Aldo J. Peixoto,Susan T. Crowley,Gary V. Desir +9 more
TL;DR: Renalase is identified as a novel flavin adenine dinucleotide-dependent amine oxidase that is secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure.
Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.
Zhirong Jiang,John R. Asplin,Andrew P. Evan,Vazhaikkurichi M. Rajendran,Heino Velazquez,Timothy Nottoli,Henry J. Binder,Peter S. Aronson +7 more
TL;DR: It is concluded that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalates urolithiasis.
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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
Sekiya Shibazaki,Zhiheng Yu,Saori Nishio,Xin Tian,R. Brent Thomson,Michihiro Mitobe,Angeliki Louvi,Heino Velazquez,Shuta Ishibe,Lloyd G. Cantley,Peter Igarashi,Stefan Somlo +11 more
TL;DR: Cysts in ADPKD exhibit both increased proliferation and activation of MAPK/ERK, but cyst growth is not prevented by inhibition of ERK1/2 activation.
280
Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney
Nicholas Obermüller,Paul Bernstein,Heino Velazquez,Robert F. Reilly,Doris Moser,David H. Ellison,Sebastian Bachmann +6 more
TL;DR: These experiments indicate that the TSC is expressed predominantly by DCT cells in both rat and humans, although expression extends into the CNT cells in humans, and shows that theTSC and Na+/Ca2+ exchanger are coexpressed by a subpopulation of D CT cells near the junction with the C NT.
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