Heike Stephanowitz
Leibniz Association
28 Papers
98 Citations
Heike Stephanowitz is an academic researcher from Leibniz Association. The author has contributed to research in topics: Chemistry & Signal peptide. The author has an hindex of 10, co-authored 26 publications. Previous affiliations of Heike Stephanowitz include Leibniz Institute for Neurobiology.
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Papers
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.
Claudio Iacobucci,Christine Piotrowski,Ruedi Aebersold,Ruedi Aebersold,Bruno C. Amaral,Philip C. Andrews,Katja Bernfur,Christoph H. Borchers,Nicolas I. Brodie,James E. Bruce,Yong Cao,Stéphane Chaignepain,Juan D. Chavez,Stéphane Claverol,Jürgen Cox,Trisha N. Davis,Gianluca Degliesposti,Meng-Qiu Dong,Nufar Edinger,Cecilia Emanuelsson,Michael Götze,Francisco Gomes-Neto,Fabio C. Gozzo,Craig B. Gutierrez,Caroline Haupt,Albert J. R. Heck,Franz Herzog,Lan Huang,Michael R. Hoopmann,Nir Kalisman,Oleg Klykov,Zdeněk Kukačka,Fan Liu,Michael J. MacCoss,Karl Mechtler,Ravit Mesika,Robert L. Moritz,Nagarjuna Nagaraj,Victor Nesati,Ana G.C. Neves-Ferreira,Robert Ninnis,Petr Novák,Francis J. O’Reilly,Matthias Pelzing,Evgeniy V. Petrotchenko,Lolita Piersimoni,Manolo Plasencia,Tara L. Pukala,Kasper D. Rand,Juri Rappsilber,Juri Rappsilber,Dana Reichmann,Carolin Sailer,Chris P. Sarnowski,Chris P. Sarnowski,Richard A. Scheltema,Carla Schmidt,David C. Schriemer,Yi Shi,J. Mark Skehel,Moriya Slavin,Frank Sobott,Frank Sobott,Victor Solis-Mezarino,Heike Stephanowitz,Florian Stengel,Christian E. Stieger,Esben Trabjerg,Michael J. Trnka,Marta Vilaseca,Rosa Viner,Yufei Xiang,Şule Yılmaz,Alex Zelter,Daniel S. Ziemianowicz,Alexander Leitner,Andrea Sinz +76 more
TL;DR: This first, community-based harmonization study onXL-MS is based on the results of 32 groups participating worldwide and builds the framework for establishing best practice guidelines to conduct cross-linking experiments, perform data analysis, and define reporting formats with the ultimate goal of assisting scientists to generate accurate and reproducible XL-MS results.
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Structural changes of TasA in biofilm formation of Bacillus subtilis
Anne Diehl,Yvette Roske,Linda J. Ball,Anup Chowdhury,Matthias Hiller,Noël Molière,Regina Kramer,Daniel Stöppler,Catherine L. Worth,Brigitte Schlegel,Martina Leidert,Nils Cremer,Natalja Erdmann,Daniel Lopez,Heike Stephanowitz,Eberhard Krause,Barth-Jan van Rossum,Peter Schmieder,Udo Heinemann,Udo Heinemann,Kürşad Turgay,Ümit Akbey,Hartmut Oschkinat +22 more
TL;DR: The experiments with the secreted major biofilm protein TasA characterize on a molecular level in vivo the transition of a folded protein into protease-resistant biofilm-stabilizing fibrils, indicating a structural change from a globular state to a fibrillar form in a functional prokaryotic system on the molecular level.
116
Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.
Sabrina Gohlke,Vyacheslav Zagoriy,Alvaro Cuadros Inostroza,Michaël Méret,Carola Mancini,Lukasz Japtok,Fabian Schumacher,Doreen Kuhlow,Antonia Graja,Heike Stephanowitz,Markus Jähnert,Eberhard Krause,Andreas Wernitz,Klaus-Jürgen Petzke,Annette Schürmann,Burkhard Kleuser,Tim J. Schulz +16 more
TL;DR: Functional analyses show that changes in specific lipid species, as observed during aging, may contribute to reduced thermogenic potential, thereby providing potential treatment strategies of age-related metabolic conditions.
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Oxidative inactivation of the endogenous antioxidant protein DJ-1 by the food contaminants 3-MCPD and 2-MCPD
Thorsten Buhrke,Linn Voss,Anja Briese,Heike Stephanowitz,Eberhard Krause,Albert Braeuning,Alfonso Lampen +6 more
TL;DR: It is shown that the endogenous antioxidant protein DJ-1 was strongly deregulated at the protein level in kidney, liver, and testis of the experimental animals that had been treated either with 3-MCPD, 2- MCPD or their dipalmitate esters, and that this deregulation is due to the oxidation of a conserved, redox-active cysteine residue ofDJ-1 to a cysteined sulfonic acid which is equivalent to loss of function of DJ-
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Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions.
Heike Stephanowitz,Sabine Lange,Diana Lang,Christian Freund,Christian Freund,Eberhard Krause +5 more
TL;DR: An improved offline 2-D liquid chromatography-MS/MS approach for the identification and quantification of binding proteins utilizing reversed-phase capillary columns with acidic acetonitrile-containing eluents in both chromatographic dimensions is developed.
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