Heike Grabsch
Maastricht University
21 Papers
81 Citations
Heike Grabsch is an academic researcher from Maastricht University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 18, co-authored 21 publications. Previous affiliations of Heike Grabsch include University of Leeds & Okayama University.
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Papers
Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
TL;DR: Using gene expression signatures, this paper identified major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival, and devised an in-silico strategy to map patterns of pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality.
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Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
- 01 Oct 2009
TL;DR: Using gene expression signatures, an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers showed reproducible and significant survival differences in multiple cohorts, suggesting that pathway interactions may play an important role in influencing disease behavior.
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Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer
Yonghui Wu,Heike Grabsch,Tatiana Ivanova,Iain Beehuat Tan,Jacinta Murray,Chia Huey Ooi,A Wright,Nicholas P. West,Gordon G A Hutchins,Jeanie Wu,Minghui Lee,Julian Lee,Jun Hao Koo,Khay Guan Yeoh,Nicole C.T. van Grieken,Bauke Ylstra,Sun Young Rha,Jaffer A. Ajani,Jae Ho Cheong,Sung Hoon Noh,Kiat Hon Lim,Alex Boussioutas,Alex Boussioutas,Ju Seog Lee,Patrick Tan,Patrick Tan +25 more
TL;DR: Stromal gene expression predicts GC patient survival in multiple independent cohorts, and may be closely related to the intra-tumoural stroma proportion, a specific morphological GC phenotype, which suggest that therapeutic approaches targeting the GC stroma may merit evaluation.
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Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination.
Raghav Sundar,Drolaiz H. W. Liu,Gordon G A Hutchins,Hayley L. Slaney,Arnaldo N. S. Silva,Jan Oosting,Jeremy D. Hayden,Lindsay C. Hewitt,Cedric Cy Ng,Amrita Mangalvedhekar,Sarah B Ng,Iain Bh Tan,Patrick Tan,Heike Grabsch +13 more
TL;DR: Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.
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Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Josien C. Haan,Tineke E. Buffart,Paul P. Eijk,M.A. van de Wiel,M.A. van de Wiel,W.N. van Wieringen,W.N. van Wieringen,Peter D. Howdle,Chris J. J. Mulder,C.J.H. van de Velde,Philip Quirke,Iris D. Nagtegaal,N.C.T. van Grieken,Heike Grabsch,Gerrit A. Meijer,Bauke Ylstra +15 more
TL;DR: It is shown that MSS SBAs are more similar to colorectal than to gastric cancer, based on the 27 genome-wide DNA copy number profiles that are currently available, and these molecular similarities provide added support for treatment of MSS small bowel cancers according to colOREctal cancer regimens.
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