Heidi M. Hoffmann
University of Massachusetts Medical School
6 Papers
76 Citations
Heidi M. Hoffmann is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Osteocalcin & Transcription factor. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Heidi M. Hoffmann include University of Massachusetts Amherst.
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Papers
Stage-Specific Expression of Dlx-5 during Osteoblast Differentiation: Involvement in Regulation of Osteocalcin Gene Expression
Hyun-Mo Ryoo,Hyun-Mo Ryoo,Heidi M. Hoffmann,T. L. Beumer,Baruch Frenkel,Dwight A. Towler,Gary S. Stein,Janet L. Stein,A. J. Van Wijnen,J. B. Lian +9 more
TL;DR: Northern blot analysis and competitive RT-PCR demonstrated that Dlx-5 and the bone-specific osteocalcin genes exhibit similar up-regulated expression during the mineralization period of osteoblast differentiation.
Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins.
Heidi M. Hoffmann,K M Catron,A. J. Van Wijnen,Laura R. McCabe,J. B. Lian,Gary S. Stein,Janet L. Stein +6 more
TL;DR: A role for Msx-1 and -2 or related homeodomain proteins in transcription of the osteocalcin gene is suggested by the combined application of mutagenesis and site-specific protein recognition analysis.
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Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor Hox proteins that bind the OC box
Heidi M. Hoffmann,T. L. Beumer,S. Rahman,Laura R. McCabe,Chaitali Banerjee,Fauzia Aslam,J. A. Tiro,A. J. Van Wijnen,Janet L. Stein,Gary S. Stein,J. B. Lian +10 more
TL;DR: In this article, the authors demonstrate association of at least two classes of tissue-restricted transcription factors with the OC box element, the OCBP and Msx proteins, supporting the concept that these sequences contribute to defining tissue specificity.
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•Journal Article
The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A
Maria F. van Gurp,Jitesh Pratap,Mai X. Luong,Amjad Javed,Heidi M. Hoffmann,Antonio Giordano,Janet L. Stein,Ellis J. Neufeld,Jane B. Lian,Gary S. Stein,Andre J. Van Wijnen +10 more
TL;DR: It is demonstrated that the CCAAT displacement protein (CDP), a transcription factor related to the cut homeodomain protein in Drosophila melanogaster, may regulate bone-specific gene transcription in immature proliferating osteoblasts and may represent an important component of a cell signaling mechanism that provides cross-talk between developmental and cell cycle-related transcriptional regulators to suppress bone tissue-specific genes during proliferative stages of osteoblast differentiation.
The Osteocalcin Gene Promoter Provides a Molecular Blueprint for Regulatory Mechanisms Controlling Bone Tissue Formation: Role of Transcription Factors Involved in Development
Jane B. Lian,Gary S. Stein,Janet L. Stein,Andre J. Van Wijnen,Laura R. McCabe,Chaitali Banerjee,Heidi M. Hoffmann +6 more
TL;DR: Evidence is presented for AP-1 motifs and two multipartite conserved regulatory sequences, the OC Box I and a site designated OC Box II, in contributing to developmental and tissue-specific expression of osteocalcin.
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