Heidi J. Long
Boston University
8 Papers
111 Citations
Heidi J. Long is an academic researcher from Boston University. The author has contributed to research in topics: Platelet activation & Amyloid precursor protein. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Heidi J. Long include United States Department of Veterans Affairs & University of California, Irvine.
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Papers
Initial cytoplasmic and phagosomal consequences of human neutrophil exposure to Staphylococcus epidermidis.
TL;DR: It is found that opsonization is required for functional activation of PMN by Se, that the organism causes early alkalinization of the phagosome (in contrast to Cf which hyperacidifies it), and that extracellular Ca2+ is not required for cytoplasmic Ca2- signaling but contributes markedly to binding of Se to PMN and to ensuant bactericidal functions.
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Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein.
Theresa A. Davies,Theresa A. Davies,Theresa A. Davies,Andrea M. Billingslea,Andrea M. Billingslea,Andrea M. Billingslea,Heidi J. Long,Heidi J. Long,Heidi J. Long,Heather Tibbles,Heather Tibbles,Heather Tibbles,John M. Wells,John M. Wells,John M. Wells,Patricia B. Eisenhalier,Patricia B. Eisenhalier,Patricia B. Eisenhalier,Sally J. Smith,Sally J. Smith,Sally J. Smith,David H. Cribbs,David H. Cribbs,David H. Cribbs,Richard E. Fine,Richard E. Fine,Richard E. Fine,Elizabeth R. Simons,Elizabeth R. Simons,Elizabeth R. Simons +29 more
TL;DR: The interaction between platelets, the APP they have retained or released, and cerebral vascular endothelial cells may be at least partially responsible for amyloidogenic deposits around the cerebral vasculature of AD patients.
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Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases
Elizabeth R. Simons,Derek C.L. Marshall,Heidi J. Long,Kim Otto,Andrea M. Billingslea,Heather Tibbles,John Henry Wells,Patricia B. Eisenhauer,Richard E. Fine,David H. Cribbs,Theresa A. Davies,Carmela R. Abraham +11 more
TL;DR: It is reported here that an endothelial cell-derived enzyme can cleave this surface platelet A beta PP, and the data suggest that E.C.4.3.24.15 synthesized by brain endothelial cells may process the platelet-derived A betaPP, yielding fragments which could contribute to cerebrovascular A beta deposits.
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Sequential chemotactic and phagocytic activation of human polymorphonuclear neutrophils.
Jens Martin Herrmann,John Bernardo,Heidi J. Long,Kurt F. Seetoo,Mary E. McMenamin,Eraldo L. Batista,Thomas E. Van Dyke,Elizabeth R. Simons +7 more
TL;DR: The initial signaling involved in these functions were explored by observing naïve, unprimed PMN in suspension using fluorescent indicators of cytoplasmic signals (Δ[Ca2+]i and ΔpHi) and of bactericidal entities exposed to N-formyl-methionyl-leucyl-phenylalanine (fMLP) and/or multivalent immune complexes (IC).
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Platelets from patients with Alzheimer's disease or other dementias exhibit disease-specific and apolipoprotein E correlatable defects
Theresa A. Davies,Heidi J. Long,W.H. Rathbun,Kimberly R. Sgro,Heather Tibbles,Sally J. Smith,Kurt F. Seetoo,Mary E. McMenamin,Robin J. Johnson,John M. Wells,Claire Levesque,Richard E. Fine,Elizabeth R. Simons +12 more
TL;DR: It is shown that a similar hyperacidification also exists in patients with Pick's disease or Down syndrome, while the AβPP processing defect and consequent A βPP retention on the membrane is absent and is thus likely to be AD-specific.
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