Heewoo Sim
Konkuk University
5 Papers
Heewoo Sim is an academic researcher from Konkuk University. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 4, co-authored 4 publications.
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Papers
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients
Eun Sook Park,Ah Ram Lee,Doo Hyun Kim,Jeong Hoon Lee,Jeong-Ju Yoo,Sung Hyun Ahn,Heewoo Sim,Soree Park,Hong Seok Kang,Juhee Won,Yea Na Ha,Gu Choul Shin,So Young Kwon,Yong Kwang Park,Byeong Sun Choi,Yun Bin Lee,Nakcheol Jeong,Yohan An,Young Seok Ju,Su Jong Yu,Hee Bok Chae,Kyung Sang Yu,Yoon Jun Kim,Jung Hwan Yoon,Fabien Zoulim,Kyun-Hwan Kim +25 more
TL;DR: The results demonstrate that tenofovir-resistant HBV mutants can emerge, although the genetic barrier is high, and reveal that the quadruple (CYEI) mutation increases the amount of ten ofovir required to inhibit HBV by 15.3-fold in IC50 and 26.3% in IC90.
122
Multiple Functions of Cellular FLIP Are Essential for Replication of Hepatitis B Virus.
Ah Ram Lee,Keo Heun Lim,Eun Sook Park,Doo Hyun Kim,Yong Kwang Park,Soree Park,Dong-Sik Kim,Gu Choul Shin,Hong Seok Kang,Juhee Won,Heewoo Sim,Yea Na Ha,Byeongjune Jae,Seong Il Choi,Kyun-Hwan Kim +14 more
TL;DR: The knockdown of endogenous c-FLIP revealed that this protein regulates HBV replication through two different mechanisms, which may provide a new target for intervention in persistent HBV infection.
15
Co‐degradation of interferon signaling factor DDX3 by PB1‐F2 as a basis for high virulence of 1918 pandemic influenza
Eun Sook Park,Young Ho Byun,Soree Park,Yo Han Jang,Woo Ry Han,Juhee Won,Kyung Cho Cho,Doo Hyun Kim,Ah Ram Lee,Gu Choul Shin,Yong Kwang Park,Hong Seok Kang,Heewoo Sim,Yea Na Ha,Byeongjune Jae,Ahyun Son,Paul Kim,Jieun Yu,Hyemin Lee,Sun Bin Kwon,Kwang Pyo Kim,Seung Hyun Lee,Yeong Min Park,Baik Lin Seong,Kyun-Hwan Kim +24 more
TL;DR: The 1918 PB1‐F2 protein constitutes a potent IFN antagonist causative for the severe pathogenicity of the 1918 influenza strain and should be useful for the future design of new antiviral strategies against influenza pandemics.
Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR of TRIM22
Keo Heun Lim,Eun Sook Park,Doo Hyun Kim,Kyung Cho Cho,Kwang Pyo Kim,Yong Kwang Park,Sung Hyun Ahn,Seung Hwa Park,Kee Hwan Kim,Chang Wook Kim,Hong Seok Kang,Ah Ram Lee,Soree Park,Heewoo Sim,Juhee Won,Kieun Seok,Jueng Soo You,Jeong Hoon Lee,Nam-Joon Yi,Kwang-Woong Lee,Kyung-Suk Suh,Baik Lin Seong,Kyun-Hwan Kim +22 more
TL;DR: It is demonstrated that HBx suppresses the transcription of TRIM22 through a single CpG methylation in its 5′-UTR, which further reduces the IFN regulatory factor-1 binding affinity, thereby suppressing the IFn-stimulated induction of TRim22.