Heechung Kwon
University of Pittsburgh
15 Papers
76 Citations
Heechung Kwon is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Herpes simplex virus & Receptor. The author has an hindex of 7, co-authored 13 publications.
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Papers
Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus.
Hiroaki Uchida,Hiroaki Uchida,Marco Marzulli,Kenji Nakano,Kenji Nakano,Kenji Nakano,William F. Goins,Janet Chan,Chang Sook Hong,Lucia Mazzacurati,Ji Young Yoo,Amy Haseley,Hiroshi Nakashima,Hyunjung Baek,Heechung Kwon,Izumi Kumagai,Masahide Kuroki,Balveen Kaur,E. Antonio Chiocca,Paola Grandi,Justus B. Cohen,Joseph C. Glorioso +21 more
TL;DR: An approach to HSV retargeting that is effective in a glioma model and may be applicable to the treatment of a broad range of tumor types is described.
Human salivary gland stem cells ameliorate hyposalivation of radiation-damaged rat salivary glands
Jae Min Jeong,Hyun-Jung Baek,Yoon Ju Kim,Young Wook Choi,Heekyung Lee,Eun-Ju Lee,Eun Sook Kim,Jeong Hun Hah,Tack Kyun Kwon,Ik Joon Choi,Heechung Kwon +10 more
TL;DR: The data suggest that the isolated hSGSCs, which may have characteristics of mesenchymal-like stem cells, could be used as a cell therapy agent for the damaged salivary gland.
Soluble V Domain of Nectin-1/HveC Enables Entry of Herpes Simplex Virus Type 1 (HSV-1) into HSV-Resistant Cells by Binding to Viral Glycoprotein D
Heechung Kwon,Qing Bai,Hyunjung Baek,Kelly Felmet,Edward A. Burton,William F. Goins,Justus B. Cohen,Joseph C. Glorioso +7 more
TL;DR: The results demonstrate that the attachment function of gD is dispensable for entry provided that other means of attachment are available, such as gB and gC binding to cell surface glycosaminoglycans.
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Bispecific adapter-mediated retargeting of a receptor-restricted HSV-1 vector to CEA-bearing tumor cells.
Hyunjung Baek,Hiroaki Uchida,Kyungok Jun,Jae Hong Kim,Masahide Kuroki,Justus B. Cohen,Joseph C. Glorioso,Heechung Kwon +7 more
TL;DR: The development of an adapter connecting gD to the common tumor antigen carcinoembryonic antigen (CEA) is described, which enabled infection of HSV-resistant Chinese hamster ovary cells expressing ectopic CEA and nectin-1/CEA-bearing human gastric carcinoma cells that are resistant to the vector alone.
Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens.
Hiroaki Uchida,Hirofumi Hamada,Kenji Nakano,Heechung Kwon,Hideaki Tahara,Justus B. Cohen,Joseph C. Glorioso +6 more
TL;DR: Retargeted HSV vectors offer an attractive platform for the creation of a new generation of oncolytic HSV with improved efficacy and specificity and the potential to achieve tumor specificity at the stage of virus entry, eliminating the need for replication-attenuating mutations.
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