Hedy Smith
Tufts Medical Center
32 Papers
359 Citations
Hedy Smith is an academic researcher from Tufts Medical Center. The author has contributed to research in topics: CD8 & T-cell receptor. The author has an hindex of 18, co-authored 32 publications. Previous affiliations of Hedy Smith include Washington University in St. Louis & Westmead Hospital.
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Papers
Efficacy and safety of OBI‐1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A
Rebecca Kruse-Jarres,Jean St-Louis,Anne Greist,Amy D. Shapiro,Hedy Smith,Pratima Chowdary,A. Drebes,Edward D. Gomperts,C. Bourgeois,Min Mo,Aaron Novack,Heinrich D. Farin,Bruce M. Ewenstein +12 more
TL;DR: The ability to safely and effectively titrate dosing based on FVIII activity levels in this study demonstrates that OBI‐1 fulfils the unmet medical need to monitor the key coagulation parameter in AHA patients.
176
•Journal Article
Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy.
TL;DR: Male and female spleen cells suppress disease with comparable efficiency, and deprivation of endogenous ovarian Ag by neonatal ovariectomy of cell donors had no observable effect on disease suppression.
109
Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.
TL;DR: It is determined that PAR4 activation by thrombin occurs well after ADP release from dense granules in normal individuals, and the strong signal emanating from PAR4 during platelet aggregation would provide an explanation for the mild bleeding diathesis of HPS.
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Recombinant LH (lutropin alfa) for the treatment of hypogonadotrophic women with profound LH deficiency: a randomized, double‐blind, placebo‐controlled, proof‐of‐efficacy study
TL;DR: The aim is to confirm the safety and efficacy of 75 IU lutropin alfa with concomitant follitropinAlfa in inducing follicular development in women with profound gonadotrophin deficiency.
70
•Journal Article
T cell receptor alpha-chain influences reactivity to Mls-1 in V beta 8.1 transgenic mice.
TL;DR: A role for the TCR alpha-chain in superantigen reactivity and T cell tolerance is defined and a structural explanation for the different fates of M1s-1-reactive T cells in normal and transgenic mice is provided.
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