Heather Tibbles
Boston University
7 Papers
114 Citations
Heather Tibbles is an academic researcher from Boston University. The author has contributed to research in topics: Amyloid precursor protein & Platelet activation. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Heather Tibbles include United States Department of Veterans Affairs & University of California, Irvine.
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Papers
Activated Alzheimer Disease Platelets Retain More Beta Amyloid Precursor Protein
Theresa A. Davies,Heidi Long,K.R Sgro,W.H. Rathbun,Mary E. McMenamin,Kurt F. Seetoo,Heather Tibbles,Andrea M. Billingslea,Richard E. Fine,J.B Fishman,C.A Levesque,Sally J. Smith,John M. Wells,Elizabeth R. Simons +13 more
TL;DR: Activated platelets from AD patients exhibit less APP processing, retain more of the protein on their surface, and secrete less as soluble fragments than do controls, which suggest a processing defect that may account for greater deposition of A beta-containing products in the vasculature to which activated platelets adhere.
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Moderate and Advanced Alzheimer's Patients Exhibit Platelet Activation Differences
Theresa A. Davies,Heidi Long,Heather Tibbles,K.R Sgro,John M. Wells,W.H Rathbun,Kurt F. Seetoo,M.E McMenamin,Sally J. Smith,R.G Feldman,C.A Levesque,Richard E. Fine,Richard E. Fine,Elizabeth R. Simons +13 more
TL;DR: Thrombin-activated platelets from moderate AD patients do not exhibit either hyperacidification or APP retention; their APP processing and secretion are normal by Western blotting, suggesting that the two platelet defects appear in the advanced stages of AD.
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Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein.
Theresa A. Davies,Theresa A. Davies,Theresa A. Davies,Andrea M. Billingslea,Andrea M. Billingslea,Andrea M. Billingslea,Heidi J. Long,Heidi J. Long,Heidi J. Long,Heather Tibbles,Heather Tibbles,Heather Tibbles,John M. Wells,John M. Wells,John M. Wells,Patricia B. Eisenhalier,Patricia B. Eisenhalier,Patricia B. Eisenhalier,Sally J. Smith,Sally J. Smith,Sally J. Smith,David H. Cribbs,David H. Cribbs,David H. Cribbs,Richard E. Fine,Richard E. Fine,Richard E. Fine,Elizabeth R. Simons,Elizabeth R. Simons,Elizabeth R. Simons +29 more
TL;DR: The interaction between platelets, the APP they have retained or released, and cerebral vascular endothelial cells may be at least partially responsible for amyloidogenic deposits around the cerebral vasculature of AD patients.
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Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases
Elizabeth R. Simons,Derek C.L. Marshall,Heidi J. Long,Kim Otto,Andrea M. Billingslea,Heather Tibbles,John Henry Wells,Patricia B. Eisenhauer,Richard E. Fine,David H. Cribbs,Theresa A. Davies,Carmela R. Abraham +11 more
TL;DR: It is reported here that an endothelial cell-derived enzyme can cleave this surface platelet A beta PP, and the data suggest that E.C.4.3.24.15 synthesized by brain endothelial cells may process the platelet-derived A betaPP, yielding fragments which could contribute to cerebrovascular A beta deposits.
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Stimulus responses and amyloid precursor protein processing in DAMI megakaryocytes
Theresa A. Davies,Andrea M. Billingslea,Robin J. Johnson,Sheryl M. Greenberg,Maria F. Ortiz,Heidi Long,Kim Sgro,Heather Tibbles,Kurt F. Seetoo,W.H. Rathbun,Jeremy E. Schonhorn,Elizabeth R. Simons +11 more
TL;DR: DAMI cell culture with 35S-labeled methionine confirmed that megakaryocytes synthesize large amounts of APP, of slightly higher molecular weight, and degrade their APP extensively before platelets are formed.
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