Heather Shappell
Johns Hopkins University
18 Papers
3 Citations
Heather Shappell is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Haplotype. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Heather Shappell include Boston University.
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Papers
Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome
Leslie B. Gordon,Leslie B. Gordon,Heather Shappell,Joseph M. Massaro,Ralph B. D'Agostino,Joan F. Brazier,Susan E. Campbell,Monica E. Kleinman,Mark W. Kieran,Mark W. Kieran +9 more
TL;DR: Among patients with HGPS, lonafarnib monotherapy, compared with no treatment, was associated with a lower mortality rate after 2.2 years of follow-up, and the association of monotherapy using the protein farnesyltransferase inhibitor lonfarnib with mortality rate was evaluated.
Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome
Leslie B. Gordon,Monica E. Kleinman,Joseph M. Massaro,Ralph B. D'Agostino,Heather Shappell,Marie Gerhard-Herman,Leslie B. Smoot,Catherine M. Gordon,Robert H. Cleveland,Ara Nazarian,Brian D. Snyder,Nicole J. Ullrich,V. Michelle Silvera,Marilyn G. Liang,Nicolle Quinn,David T. Miller,Susanna Y. Huh,Anne A. Dowton,Kelly Littlefield,Maya Mundkur Greer,Mark W. Kieran +20 more
TL;DR: Comparisons with lonafarnib monotherapy treatment reveal additional bone mineral density benefit but likely no added cardiovascular benefit with the addition of pravastatin and zoledronic acid.
Children with attention-deficit/hyperactivity disorder spend more time in hyperconnected network states and less time in segregated network states as revealed by dynamic connectivity analysis.
Heather Shappell,Kelly A. Duffy,Keri S. Rosch,Keri S. Rosch,James J. Pekar,James J. Pekar,Stewart H. Mostofsky,Stewart H. Mostofsky,Martin A. Lindquist,Jessica R. Cohen +9 more
TL;DR: It is found that children with ADHD spent less total time in, and switched more quickly out of, anticorrelated states involving the default mode network and task-relevant networks as compared to TD children, implying that disrupted FC dynamics may be a mechanism underlying the behavioral symptoms and cognitive deficits commonly observed in children withADHD.
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A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.
Vinod Vathipadiekal,John J. Farrell,Shuai Wang,Heather L. Edward,Heather Shappell,Abdullah M. Al-Rubaish,Fahad Al-Muhanna,Zaki A. Naserullah,Ahmed M. Al-Suliman,Hatem O. Qutub,Irene Simkin,Lindsay A. Farrer,Zhihua Jiang,Hong-Yuan Luo,Shengwen Huang,Gustavo Mostoslavsky,George J. Murphy,P.K. Patra,David H.K. Chui,Abdulrahman Alsultan,Amein K. Al-Ali,Paola Sebastiani,Martin H. Steinberg +22 more
TL;DR: An intronic single nucleotide polymorphism in ANTXR1, an anthrax toxin receptor (chromosome 2p13), contributes to the variation in HbF in Saudi AI haplotype sickle cell anemia and is the first gene in trans to HBB that is associated with HBF only in carriers of the SaudiAI haplotype.
An Integrated Supported Employment and Education Model: Exploratory Study of an Innovative Approach Designed to Better Meet the Needs of Young Adults with Psychiatric Conditions
TL;DR: There are few tested supported education interventions and few models that integrate both supported employment (SE) and education (SEd), though recent demonstrations suggest promise.
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