Heather Leu
University of California, San Diego
17 Papers
60 Citations
Heather Leu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & Leukemia. The author has an hindex of 6, co-authored 17 publications.
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Papers
Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma.
Elisa Lazzari,Phoebe Mondala,Nathaniel Delos Santos,Amber Miller,Gabriel Pineda,Qingfei Jiang,Heather Leu,Shawn Ali,Anusha-Preethi Ganesan,Christina C. N. Wu,Caitlin Costello,Mark D. Minden,Raffaella Chiaramonte,A. Â. Keith Stewart,Leslie Crews,Catriona Jamieson +15 more
TL;DR: It is shown that expression of ADar1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance, andADAR1 knockdown reduces regeneration of high-risk MM in serially transplantable patient-derived xenografts.
Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation
Qingfei Jiang,Jane Isquith,Maria A. Zipeto,Raymond Diep,Jessica Pham,Nathan Delos Santos,Eduardo Reynoso,Julisia Chau,Heather Leu,Elisa Lazzari,Etienne Melese,Wenxue Ma,Rongxin Fang,Rongxin Fang,Mark D. Minden,Sheldon R. Morris,Bing Ren,Bing Ren,Gabriel Pineda,Frida Holm,Catriona Jamieson +20 more
TL;DR: It is shown that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a maturation, which represses CDKN1A expression indirectly via EZH2, thereby accelerating cell-cycle transit and enhancing blast crisis progenitor propagation.
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A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions
Omer A. Raheem,Anna A. Kulidjian,Christina C.N. Wu,Young B Jeong,Young B Jeong,Tomonori Yamaguchi,Kristen M. Smith,Daniel Goff,Heather Leu,Sheldon R. Morris,Nicholas A. Cacalano,Koichi Masuda,Catriona Jamieson,Christopher J. Kane,Christina Jamieson +14 more
TL;DR: PCSD1 (Prostate Cancer San Diego 1), a novel patient-derived intra-femoral xenograft model of prostate bone metastatic cancer that recapitulates mixed osteolytic and osteoblastic lesions, is reported on.
Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist
Alice Y. Shih,Annelie Schairer,Christian L. Barrett,Ifat Geron,Angela Court Recart,Daniel Goff,Sacha L. Prashad,Jerry Wu,Qingfei Jiang,Jason Gotlib,Larisa Balaian,Mark D. Minden,Heather Leu,Russell Wall,Wenxue Ma,Kamran Shazand,John Douglas Mcpherson,Steven M. Kornblau,Ida Deichaite,Minya Pu,Lei Bao,Giovanni Martinelli,Tannishtha Reya,Sheldon R. Morris,Todd VanArsdale,Thomas J. Hudson,Karen Messer,Hanna K. A. Mikkola,Wendy J. Levin,Kelly A. Frazer,Anil Sadarangani,Catriona Jamieson +31 more
TL;DR: It is suggested that implementation of novel LSC splice isoform detection platforms to assess efficacy of Shh inhibitor-mediated sensitization to molecularly targeted therapy may inform dormant cancer stem cell elimination strategies that ultimately avert relapse.
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Combination Targeted Therapy to Impair Self-Renewal Capacity of Human Blast Crisis Leukemia Stem Cells
Angela Court Recart,Anil Sadarangani,Daniel Goff,Alice Y. Shih,Russell Wall,Heather Leu,Wenxue Ma,Christian L. Barrett,Kelly A. Frazer,Elizabeth Chun,Marco A. Marra,Catriona Jamieson +11 more
TL;DR: A significant reduction in LSC serial transplantation only following combination treatment is observed, suggesting that the combination therapy can abolish LSC self-renewal capacity and thereby potentially prevent relapse.
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