Heather E. Talbott
10 Papers
Heather E. Talbott is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 8 publications.
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Papers
Wound healing, fibroblast heterogeneity, and fibrosis.
TL;DR: Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis, and the mechanisms by which they contribute to both physiologic and pathologic states of extracellular matrix deposition and remodeling are just starting to be understood as mentioned in this paper .
301
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing.
Shamik Mascharak,Heather E. Talbott,Michael Januszyk,Michelle Griffin,Kellen Chen,Michael F. Davitt,Janos Demeter,Dominic Henn,Clark A. Bonham,Deshka S. Foster,Nancie Mooney,Ran Cheng,Peter K. Jackson,Derrick C. Wan,Geoffrey C. Gurtner,Michael T. Longaker +15 more
TL;DR: The divergent molecular events driving skin wound cells toward scarring or regenerative fates are reported and Trps1 is identified as a key regulatory gene that is necessary and partially sufficient for wound regeneration.
128
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.
Deshka S. Foster,Michael Januszyk,Daniel Delitto,Kathryn E. Yost,Michelle Griffin,Jason Guo,Nicholas Guardino,Andrea E. Delitto,Malini Chinta,Austin R. Burcham,Alan T. Nguyen,Khristian E. Bauer-Rowe,Ashley L. Titan,Ankit Salhotra,R. Ellen Jones,Oscar da Silva,Hunter G. Lindsay,Charlotte E. Berry,Kellen Chen,Dominic Henn,Shamik Mascharak,Heather E. Talbott,Alex S. Kim,Fatemeh Nosrati,Dharshan Sivaraj,Ryan C. Ransom,Michael Matthews,Anum Khan,Dhananjay A. Wagh,John Van Coller,Geoffrey C. Gurtner,Derrick C. Wan,Irene Wapnir,Howard Y. Chang,Jeffrey A. Norton,Michael T. Longaker +35 more
TL;DR: In this paper , the authors used paired, same-cell chromatin accessibility and transcriptome analysis to identify three superclusters: steady state-like (SSL), mechanoresponsive (MR), and immunomodulatory (IM) CAFs.
113
Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model.
Shamik Mascharak,Michelle Griffin,Heather E. Talbott,Jason L. Guo,J. Parker,A. Morgan,Caleb Valencia,Max Kuhnert,Dayan J. Li,Norah E. Liang,Rachel M. Kratofil,Joseph Daccache,Ikjot Sidhu,Michael F. Davitt,Nicholas Guardino,John M. Lu,Darren B. Abbas,Nestor M D Deleon,Christopher V. Lavin,Sandeep Adem,Anum Khan,Kellen Chen,Dominic Henn,Amanda Spielman,Asha C. Cotterell,Deena Akras,Mauricio A. Downer,Ruth Tevlin,H. P. Lorenz,Geoffrey C. Gurtner,Michael Januszyk,S.Chakravarthy Naik,Derrick C. Wan,Michael T. Longaker +33 more
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Inhibition of Yes-Associated Protein Promotes Skin Wound Regeneration in Large Animals
Michael Januszyk,Heather E. Talbott,Michelle Griffin,Nicholas Guardino,Amanda Spielman,Jason L. Guo,Shamik Mascharak,Derrick C. Wan,Michael T. Longaker +8 more
TL;DR: In this paper , verteporfin treatment was found to significantly reduce scarring and promote skin regeneration, including recovery of hair follicles and glands, in a large animal model.