Heather Bear
Cincinnati Children's Hospital Medical Center
5 Papers
15 Citations
Heather Bear is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Glioma & Gene. The author has an hindex of 2, co-authored 3 publications.
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Papers
Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation.
Smruti K. Patel,Rachel Hartley,Xin Wei,Robin Furnish,Fernanda Escobar-Riquelme,Heather Bear,Kwangmin Choi,Christine Fuller,Timothy N. Phoenix,Timothy N. Phoenix +9 more
TL;DR: Brainstem targeted in utero electroporation provides a rapid and flexible system to generate diverse DIPG mouse models that display unique histopathological and molecular features found in human DIPGs.
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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Prasidda Khadka,Zachary J. Reitman,Sophie D Lu,G Buchan,Gabrielle Gionet,Frank Dubois,Diana Carvalho,Juliann Shih,Shu Zhang,Noah F. Greenwald,Travis I. Zack,Ofer Shapira,Kristine Pelton,Rachel M. Hartley,Heather Bear,Yohanna Georgis,S. Jarmale,Randy Melanson,Kevin Bonanno,Kathleen Schoolcraft,Peter Miller,Alexandra Larisa Condurat,Elizabeth Gonzalez,Kenin Qian,Eric Morin,Jaldeep Langhnoja,Leslie E. Lupien,Veronica Rendo,Jeromy J Digiacomo,Dayle K Wang,Kevin N Zhou,Rushil Kumbhani,Maria E. Guerra Garcia,Claire Sinai,Sarah Becker,Rachel Schneider,Jayne Vogelzang,Karsten Krug,Amy Goodale,Tanaz Abid,Zohra Kalani,Federica Piccioni,Rameen Beroukhim,Nicole Persky,David E. Root,Angel M. Carcaboso,Benjamin L. Ebert,Christine E. Fuller,O. Babur,Mark W. Kieran,Chris Jones,Hasmik Keshishian,Keith L. Ligon,Steven A. Carr,Timothy N. Phoenix,Pratiti Bandopadhayay +55 more
TL;DR: In this article , the role of PPM1D mutations in de novo gliomagenesis has been systematically explored, and it was shown that truncating mutations in PPM 1D that increase the stability of its phosphatase are clonal driver events in 11% of Diffuse Midline Gliomas (DMGs) and are enriched in primary pontine tumors.
Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model.
Zachary L. Taylor,Zachary L. Taylor,Lauren E. Thompson,Heather Bear,Tomoyuki Mizuno,Tomoyuki Mizuno,Alexander A. Vinks,Alexander A. Vinks,Laura B. Ramsey,Laura B. Ramsey +9 more
TL;DR: In this article, the authors investigated the impact of SLCO1B1 polymorphisms on the pharmacokinetics and therapeutic outcomes of low-dose methotrexate in a murine model of collagen-induced arthritis.
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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Prasidda Khadka,Zachary J. Reitman,Sophie D Lu,G Buchan,Gabrielle Gionet,Frank Dubois,Diana Carvalho,Juliann Shih,Shu Zhang,Noah F. Greenwald,Travis I. Zack,Ofer Shapira,Kristine Pelton,Rachel M. Hartley,Heather Bear,Yohanna Georgis,S. Jarmale,Randy Melanson,Kevin Bonanno,Kathleen Schoolcraft,Peter Miller,Alexandra Larisa Condurat,Elizabeth Gonzalez,Kenin Qian,Eric Morin,Jaldeep Langhnoja,Leslie E. Lupien,Veronica Rendo,Jeromy J Digiacomo,Dayle K Wang,Kevin Zhou,Rushil Kumbhani,Maria E. Guerra Garcia,Claire Sinai,Sarah Becker,Rachel Schneider,Jayne Vogelzang,Karsten Krug,Amy Goodale,Tanaz Abid,Zohra Kalani,Federica Piccioni,Rameen Beroukhim,Nicole Persky,David E. Root,Angel M. Carcaboso,Benjamin L. Ebert,Christine E. Fuller,O. Babur,Mark W. Kieran,Chris Jones,Hasmik Keshishian,Keith L. Ligon,Steven A. Carr,Timothy N. Phoenix,Pratiti Bandopadhayay +55 more
TL;DR: In this paper , the role of PPM1D mutations in de novo gliomagenesis has been systematically explored, and it was shown that truncating mutations in PPM 1D that increase the stability of its phosphatase are clonal driver events in 11% of Diffuse Midline Gliomas (DMGs) and are enriched in primary pontine tumors.