He Wang
Eli Lilly and Company
18 Papers
112 Citations
He Wang is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Nucleic acid & Kexin. The author has an hindex of 7, co-authored 18 publications.
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Papers
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
Yue-Wei Qian,Robert J. Schmidt,Youyan Zhang,Shaoyou Chu,Aimin Lin,He Wang,Xiliang Wang,Thomas P. Beyer,William R. Bensch,Weiming Li,Mariam Ehsani,Deshun Lu,Robert J. Konrad,Patrick I. Eacho,David E. Moller,Sotirios K. Karathanasis,Guoqing Cao +16 more
TL;DR: Results reveal that secreted PCSK9 retains biological activity, is able to bind directly to the LDLR extracellular domain, and undergoes LDLR-ARH-mediated endocytosis, leading to accelerated intracellular degradation of the HDLR.
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Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human
Eric T. Williams,James A. Bacon,David M. Bender,Jennifer J. Lowinger,Wen-Kai Guo,Mariam Ehsani,Xiliang Wang,He Wang,Yue-Wei Qian,Kenneth J. Ruterbories,Steven A. Wrighton,Everett J. Perkins +11 more
TL;DR: Quantitative real-time polymerase chain reaction and Western blot analyses indicate that the pattern of CES tissue expression in monkey is similar to that of human, but the CES expression in dog is unique, with no detectable expression of CES in the intestine.
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Patent
Novel secreted proteins and their uses
Brian Taylor Edmonds,Radmila Micanovic,Weijia Ou,Eric Wen Su,Sheng-Hung Rainbow Tschang,He Wang +5 more
- 30 Jul 2001
TL;DR: The present invention provides nucleic acid sequences encoding novel human proteins as discussed by the authors, which are useful for constructing the claimed DNA vectors and host cells of the invention and for preparing the claimed nucleic acids, recombinant proteins and antibodies that are useful in the claimed methods and medical uses.
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A novel splicing variant of proprotein convertase subtilisin/kexin type 9.
Robert J. Schmidt,Youyan Zhang,Yang Zhao,Yue-Wei Qian,He Wang,Aimin Lin,Maria E. Ehsani,Xiaohong Yu,Guoming Wang,Jaipal Singh,Eric Wen Su,Shuyu Li,Robert J. Konrad,Guoqing Cao +13 more
TL;DR: A novel human PCSK9 splicing variant, which had an in-frame deletion of the eighth exon of 58 amino acids and was expressed in multiple tissues, including liver, small intestine, prostate, uterus, brain, and adipose tissue, is reported.
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Genomic analysis of the carboxylesterases: identification and classification of novel forms
TL;DR: Analysis of CE genes suggest that four CE groups existed prior to mammalian divergence, with another form occurring after eutherian-marsupial divergence, yielding five distinct mammalian CE groups.
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