Transient receptor potential (TRP) channels comprise a large superfamily of channels activated under conditions associated with cellular stress including stretch, neurohormonal signaling, hypoxia, and oxidative stress. Although often considered to be operative in nonexcitable cells, emerging data suggests that these channels are critically important to the function of cells in the heart and vasculature. Dysregulation of these channels during cardiac stress contributes to the maladaptive response during cardiac disease. Here, we consider the role of the TRP channels in cardiac failure, arrhythmogenesis, and pulmonary arterial hypertension. We discuss the importance of specific channels, the signaling cascades activated by TRP channels, and potential therapeutic agents. Thus, the case is building that selective and specific antagonism of TRP channels will become an important goal.

TRP Channels in Cardiovascular Disease

Objective To isolate and identify human dental pulp stem cells from third molarsMethods Dental pulps were dissected and digested by collagenase type Ⅰ and dispase The obtained single cell supernatant were harvested and cultured Characterization of the phenotype of DPSCs was detected by immunohistochemical method and RT-PCR assay Cell cycle was analyzed by FCM Differentiation potential of DPSCs was evaluatedResults Colony-forming efficiency of cells derived from dental pulp tissue was 2～15 clones/10+3 cells plated DPSCs were found to express many different markers, including vimentin, collagen type Ⅰ, GFAP, nestin and osteocalcin, while they failed to react with MyoD and DSPP About 641% of the cells were in G_0/G_1 phases, while only 358% in proliferation (S+G_2+M) Grown in an adipogenic cocktail medium for three weeks, some DPSCs expressed fat cell markers of PPARγ and LPL, and formed oil red O-positive lipid clusters in five weeks After culture with a myogenic-inductive medium, DPSCs were found to express MyoD, desmin and myosin, markers of myocyte Long-term cultures of DPSCs grown in differentiation inductive medium demonstrated the capacity to form Von Kossa-positive condensed nodules with high levels of calciumConclusion Cells isolated from adult human dental pulp are clonogenic, and have multipotent differentiation potential, satisfying the criteria of postnatal somatic stem cell

Isolation and Identification of Human Dental Pulp Stem Cells

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Isolation and Identification of Human Dental Pulp Stem Cells