He Chen
Harbin Medical University
13 Papers
15 Citations
He Chen is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 10 publications.
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Papers
Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation
Hongyue Zhang,Ying Liu,Lixin Yan,Siqi Wang,Min Zhang,Cui Ma,Xiaodong Zheng,He Chen,Daling Zhu +8 more
TL;DR: This study defined the role and mechanism of action of Hoxaas3 in the regulation of cell proliferation in PH, which should facilitate the development of new therapeutic strategies for the treatment of this disease.
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Bone morphogenetic protein-7 inhibits endothelial-mesenchymal transition in pulmonary artery endothelial cell under hypoxia
Hongyue Zhang,Ying Liu,Lixin Yan,Wei Du,Xiaodan Zhang,Min Zhang,He Chen,Y Zhang,Jianqiu Zhou,Hanliang Sun,Daling Zhu +10 more
TL;DR: The results demonstrate that BMP‐7 attenuates the hypoxia‐induced EndoMT and cell migration by suppressing the m‐TORC1 signaling pathway and suggested a new therapeutic strategy targeting EndOMT for the treatment of pulmonary arterial hypertension.
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Arsenic trioxide promoting ETosis in acute promyelocytic leukemia through mTOR-regulated autophagy
Tao Li,Ruishuang Ma,Ruishuang Ma,Yan Zhang,Hongdan Mo,Xiaoyan Yang,Xiaoyan Yang,Shaoshan Hu,Lixiu Wang,Valerie A. Novakovic,He Chen,Junjie Kou,Yayan Bi,Bo Yu,Bo Yu,Shaohong Fang,Jinghua Wang,Jin Zhou,Jialan Shi,Jialan Shi +19 more
TL;DR: Results show that ATO exerts antileukemic effects at least partially through ETosis and targets LICs primarily throughETosis, and addition of drugs that target the ETotic pathway could be a promising therapeutic strategy to further eradicate LICs and reduce relapse.
Phosphatidylserine on blood cells and endothelial cells contributes to the hypercoagulable state in cirrhosis
Xiaoming Wu,Zhipeng Yao,Lu Zhao,Yan Zhang,Muhua Cao,Tao Li,Wenbo Ding,Yan Liu,Ruijuan Deng,Zengxiang Dong,He Chen,Valerie A. Novakovic,Yayan Bi,Junjie Kou,Ye Tian,Jin Zhou,Jialan Shi,Jialan Shi +17 more
TL;DR: The relationship between phosphatidylserine on blood cells and endothelial cells and the hypercoagulable state in cirrhotic patients was studied to study the mechanism of thrombogenicity in Cirrhosis.
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Increased blood cell phosphatidylserine exposure and circulating microparticles contribute to procoagulant activity after carotid artery stenting
Lu Zhao,Xiaoming Wu,Yu Si,Zhipeng Yao,Zengxiang Dong,Valerie A. Novakovic,Li Guo,Dongxia Tong,He Chen,Yayan Bi,Junjie Kou,Huaizhang Shi,Ye Tian,Shaoshan Hu,Jin Zhou,Jialan Shi +15 more
TL;DR: It is suggested that increased exposure of PS on blood cells and MPs may contribute to enhanced PCA in patients with ICA stenosis who have undergone CAS, explaining the risk of perioperative thromboembolic complications in these patients.
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