Hazel Painter
John Radcliffe Hospital
15 Papers
157 Citations
Hazel Painter is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 9, co-authored 15 publications.
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Papers
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
Gerry McLachlan,Heather E Davidson,Emma Holder,Lee A. Davies,Ian A. Pringle,Stephanie G. Sumner-Jones,Alison Baker,Peter Tennant,Catherine Gordon,Christina Vrettou,R. Blundell,Laura Hyndman,Barbara J Stevenson,Abigail R. Wilson,Ann Doherty,Darren J. Shaw,Rebecca Coles,Hazel Painter,S H Cheng,Ronald K. Scheule,Jane C. Davies,J A Innes,S C Hyde,Uta Griesenbach,Eric W.F.W. Alton,A. C. Boyd,David J. Porteous,Deborah R. Gill,David Collie +28 more
TL;DR: The conclusion was that GL67A was the best non-viral GTA currently available for aerosol delivery to the sheep lung, led to the selection ofGL67A as the authors' lead GTA for clinical trials in CF patients.
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Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo
Uta Griesenbach,Chris Kitson,Escudero Sara Garcia,Raymond Farley,Charanjit Singh,Luci Somerton,Hazel Painter,Rbecca L Smith,Deborah R. Gill,Stephen C. Hyde,Yu-Hua Chow,Jim Hu,Michael A. Gray,Mark R. Edbrooke,V. C. Ogilvie,Gordon MacGregor,Ronald K. Scheule,Seng H. Cheng,Natasha J. Caplen,Eric W.F.W. Alton +19 more
TL;DR: This study suggests that although siRNAs and asODNs can be developed to inhibit gene expression in culture systems and certain organs in vivo, barriers to nucleic acid transfer in airway epithelial cells seen with large DNA molecules may also affect the efficiency of in vivo uptake of smallucleic acid molecules.
Optimizing aerosol gene delivery and expression in the ovine lung.
Gerry McLachlan,Alison Baker,Peter Tennant,Catherine M. Gordon,Christina Vrettou,Louise Renwick,R. Blundell,Seng H. Cheng,Ron Scheule,Lee A. Davies,Hazel Painter,Rebecca Coles,Anna E. Lawton,Christopher Marriott,Deborah R. Gill,Stephen C. Hyde,Uta Griesenbach,Eric W.F.W. Alton,A. Christopher Boyd,David J. Porteous,David Collie +20 more
TL;DR: The sheep model can differentiate between doses of GTA and that the anticholinergic, glycopyrrolate, enhanced transgene expression is distinguished between doses, and dose-related toxicity of GTA was reduced by aerosol administration compared to direct instillation.
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Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury
K Ulrich,M Stern,M. E. Goddard,Jean Williams,Jie Zhu,A. Dewar,Hazel Painter,Peter K. Jeffery,D. R. Gill,S. C. Hyde,Duncan M. Geddes,M. Takata,Eric W.F.W. Alton +12 more
TL;DR: The feasibility of KGF as a therapy for acute lung injury is suggested and topical and systemic liposome-mediated KGF-gene delivery on ATII cell proliferation is evaluated.
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Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid–DNA complexes to ovine lung segments
Michael Emerson,Louise Renwick,Stephen Tate,Susan Rhind,Elspeth Milne,Hazel Painter,A. Christopher Boyd,Gerry McLachlan,Uta Griesenbach,Seng H Cheng,Deborah R. Gill,Stephen C. Hyde,Alison Baker,Eric W. F. W. Alton,David J. Porteous,David Collie +15 more
TL;DR: The severity of the inflammatory response appeared to correlate with the administered dose of DNA and was generally more severe for p DNA:GL67, and a significant correlation was observed between mRNA and protein expression in samples derived from airways treated with pDNA: GL67.
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