Hatem Hmidan
University of Paris
6 Papers
1 Citations
Hatem Hmidan is an academic researcher from University of Paris. The author has contributed to research in topics: Oligodendrocyte & Downregulation and upregulation. The author has an hindex of 2, co-authored 2 publications.
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Papers
Chd7 Cooperates with Sox10 and Regulates the Onset of CNS Myelination and Remyelination
Danyang He,Danyang He,Corentine Marie,Chuntao Zhao,Bong-Woo Kim,Jincheng Wang,Yaqi Deng,Adrien Clavairoly,Magali Frah,Haibo Wang,Xuelian He,Hatem Hmidan,Blaise V. Jones,David P. Witte,Bernard Zalc,Xin Zhou,Daniel I. Choo,Donna M. Martin,Carlos Parras,Q. Richard Lu,Q. Richard Lu,Q. Richard Lu +21 more
TL;DR: It is found that Chd7 is a direct transcriptional target of oligodendrogenesis-promoting factors Olig2 and Smarca4/Brg1 and is required for proper onset of CNS myelination and remyelination, and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages.
Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.
Corentine Marie,Adrien Clavairoly,Magali Frah,Hatem Hmidan,Jun Yan,Chuntao Zhao,Juliette Van Steenwinckel,Romain Daveau,Bernard Zalc,Bassem A. Hassan,Jean-Leon Thomas,Jean-Leon Thomas,Pierre Gressens,Philippe Ravassard,Ivan Moszer,Donna M. Martin,Q. Richard Lu,Carlos Parras +17 more
TL;DR: It is shown that Chd 7 protects OPCs from apoptosis by chromatin closing and gene repression of p53, while Chd7 induces chromatin opening and gene activation of OPC-differentiation regulators, which offer new avenues to understand and modulate the CHD7 and CHD8 functions in normal development and disease.
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Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation
Emeric Merour,Hatem Hmidan,Corentine Marie,Pierre-Henri Helou,Haiyang Lu,Antoine Potel,Jean-Baptiste Huré,Adrien Clavairoly,Yi Ping Shih,Salman Goudarzi,Sébastien Dussaud,Philippe Ravassard,Sassan Hafizi,Su Hao Lo,Bassem A. Hassan,Carlos Parras +15 more
TL;DR: Findings reveal a specific time window during which transcriptional upregulation of Tns3 in immature OLs is required for OL differentiation likely by mediating integrin-β1 survival signaling to the actin cytoskeleton as OL undergo the large morphological changes required for their terminal differentiation.
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Chd7 Cooperates with Sox10 and Regulates the Onset of CNS Myelination and Remyelination
Danyang He,Corentine Marie,Chuntao Zhao,Bongwoo Kim,Jincheng Wang,Yaqi Deng,Adrien Clavairoly,Magali Frah,Haibo Wang,Xuelian He,Hatem Hmidan,Blaise V Jones,David Witte,Bernard Zalc,Xin Zhou,Daniel I Choo,Donna M. Martin,Carlos Parras,Q. R. Lu +18 more
TL;DR: It is found that Chd7 is a direct transcriptional target of oligodendrogenesis-promoting factors Olig2 and Smarca4/Brg1 and is required for proper onset of CNS myelination and remyelination and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages, including oligodendrocytes and osteoblasts.
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PAK1 and NF2/Merlin jointly drive myelination by remodeling actin cytoskeleton in oligodendrocytes
Lucas Baudouin,Noémie Adès,K. Kanté,Corinne Bachelin,Hatem Hmidan,Cyrille Deboux,R. Panic,Rémy Ben Messaoud,Y. Velut,Soumia Hamada,Cédric Pionneau,Kévin Duarte,Sandrine Poëa-Guyon,Jean-Vianney Barnier,B. Oumesmar,Lamia Bouslama-Oueghlani +15 more
TL;DR: PAK1-NF2/Merlin duo plays a key role in actin cytoskeleton remodeling in OLs, required for proper myelin formation, and these findings have broad mechanistic and therapeutic implications for demyelinating diseases and neurodevelopmental disorders.
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