Harrie Weinans
Utrecht University
437 Papers
2.8K Citations
Harrie Weinans is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Osteoarthritis. The author has an hindex of 85, co-authored 413 publications. Previous affiliations of Harrie Weinans include Rush University Medical Center & Erasmus University Rotterdam.
Chat about Author
Papers
Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis
F. Intema,Y.H. Sniekers,Harrie Weinans,M. E. Vianen,Sue A. Yocum,Anne-Marie Zuurmond,Jeroen DeGroot,Floris P J G Lafeber,Simon C. Mastbergen +8 more
TL;DR: The early decrease in plate thickness, present in both models, as was cartilage damage, suggests that plate thinning is a phenomenon that is intrinsic to the process of OA independent of the cause/induction of OT, and trabecular changes in subchondral and metaphyseal bone are not part of a common pathway of Oa development.
77
•Journal Article
Microstructure and biomechanical characteristics of bone substitutes for trauma and orthopaedic surgery
TL;DR: The bone substitute cements tested display a wide range in structural properties and compression strength, indicating that they will be suitable for different clinical indications.
76
In situ forming acyl-capped PCLA-PEG-PCLA triblock copolymer based hydrogels.
Maria J. Sandker,Audrey Petit,Everaldo M. Redout,Michiel Siebelt,Benno Müller,Peter Bruin,Ronald Meyboom,Tina Vermonden,Wim E. Hennink,Harrie Weinans +9 more
TL;DR: Good cytocompatibility of acetyl-capped polymer based hydrogel was proven in vitro on erythrocytes and chondrocytes, and intra-articular biocomp compatibility was demonstrated using μCT-imaging and histology, since both techniques showed no changes in cartilage quality and/or quantity.
76
Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing
Laoise M. McNamara,A. G. H. Ederveen,C.G. Lyons,Colles Price,Mitchell B. Schaffler,Harrie Weinans,Patrick J. Prendergast +6 more
TL;DR: The results indicate that ovariectomy in rats increases the stiffness, yield strength, yield strain and ultimate stress of the mineralized tissue constituting trabecular bone relative to normal, and suggest that, in addition to the effects of osteoporosis and subsequent treatment on bone architecture, there are also more subtle processes ongoing to alter bone strength at the tissue level.
73
Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties
J. S. Day,Ming Ding,P. Bednarz,P. Bednarz,J.C. van der Linden,Tasuku Mashiba,T. Hirano,C. Conrad Johnston,David B. Burr,Ivan Hvid,Dale R. Sumner,Harrie Weinans +11 more
TL;DR: Bisphosphonates are emerging as an important treatment for osteoporosis, and it is hypothesized that the expected increase in the Young's modulus of the calcified matrix due to the increased calcification matrix density was counteracted by the accumulation of microdamage.
73