Harpal S. Kumar
5 Papers
Harpal S. Kumar is an academic researcher. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 1, co-authored 1 publications.
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Papers
Cell-Free DNA–Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial
Richard D Neal,Peter Johnson,Christina A. Clarke,Stephanie A. Hamilton,Nan Zhang,Harpal S. Kumar,Charles Swanton,Peter Sasieni +7 more
TL;DR: Whether a multi-cancer early detection (MCED) test that screens asymptomatic individuals for cancer can reduce late-stage cancer incidence is established and the clinical utility of population screening with an MCED test is determined.
NHS-Galleri Trial Design: Equitable study recruitment tactics for targeted population-level screening with a multi-cancer early detection (MCED) test.
Charles Swanton,Richard D Neal,Peter W. M. Johnson,Christina Clarke Dur,Stephanie A. Hamilton,N. Zhang,Harpal S. Kumar,Peter Sasieni +7 more
TL;DR: The NHS-Galleri trial is a randomized controlled trial assessing the clinical utility of this MCED test in a targeted screening population alongside current screening programs, and a significant reduction in the absolute numbers of stage III & IV cancers diagnosed in the intervention versus control arm 3.5 years after randomization.
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Large-scale observational prospective cohort study of a multi-cancer early detection (MCED) test in symptomatic patients referred for cancer investigation.
Brian Nicholson,Dean A. Harris,Catherine A O'Doherty,P S Virdee,Sharon Tonner,M. Vargova,Lazarina Engonidou,Kaveh Riahi,Ying Luan,Sara Hiom,Harpal S. Kumar,Kathryn N. Kurtzman,Ly Me Yu,Sarah Pearson,Rafael Perera,Mark R. Middleton +15 more
TL;DR: In this paper , the authors evaluated the performance of a next-generation sequencing MCED test (GRAIL, LLC) using cell-free DNA (cfDNA) isolated from whole blood in symptomatic patients referred to cancer diagnostic clinics by their primary care physician.
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Addressing the Growing International Challenge of Cancer: A Multinational Perspective
Harold E. Varmus,Harpal S. Kumar +1 more
TL;DR: Recommendations are presented that leaders in cancer research and policy from 15 economically diverse countries believe will enable faster progress in addressing the growing international challenge of cancer.
Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study.
Brian Nicholson,Jason Oke,P S Virdee,Dean A. Harris,Catherine A O'Doherty,Zaed Z R Hamady,Vinay Sehgal,Andrew Millar,Louise C. Medley,Sharon Tonner,Lazarina Engonidou,Kaveh Riahi,Ying Luan,Sara Hiom,Harpal S. Kumar,Kathryn N. Kurtzman,Ly-Mee Yu,Sarah Pearson,FD Richard Hobbs,Rafael Perera,Mark R. Middleton +20 more
TL;DR: This first large-scale prospective evaluation of a methylation-based multicancer early detection (MCED) diagnostic test in a symptomatic population demonstrates the feasibility of using an MCED test to assist clinicians with decisions regarding urgency and route of referral from primary care.