Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
Unfolding and refolding of the native structure of bovine pancreatic trypsin inhibitor studied by computer simulations
TL;DR: The results presented here support a general model for protein folding, i.e., progressive formation of partially folded structural units, followed by collapse to the compact native structure.
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Crystal structures of two mutants that have implications for the folding of bovine pancreatic ribonuclease A
TL;DR: Although there is disorder in the region of residues 92 and 93, the best structural model contains a cis peptide at this position, lending support to the results of the kinetics experiments, and reports the crystal structure of the P93A variant of RNase A, missing the 40‐95 disulfide bond.
Kinetics and mechanism of the refolding of denatured ribonuclease A
TL;DR: A refolding scheme involving one intermediate on each of the two slow-folding pathways is proposed by adopting the notion that RNase A refolds through a sequential mechanism and it is shown that such aRefolding scheme can account for the known kinetic features of both major and minor slow-refolding pathways ofRNase A.
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Assay of bovine fibrinopeptides by high performance liquid chromatography.
TL;DR: A method for separating small amounts of bovine fibrinopeptides A and B employing high performance liquid chromatography using isocratic elution with aqueous buffer-acetonitrile solvent systems has been developed.
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