Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
U-3′-BCIP: a chromogenic substrate for the detection of RNase A in recombinant DNA expression systems
Mark R. Witmer,Caterina M. Falcomer,Michael P. Weiner,Michael S. Kay,Tadhg P. Begley,Bruce Ganem,Harold A. Scheraga +6 more
TL;DR: The synthesis of the bovine pancreatic ribonuclease A chromogenic substrate uridine-3'-(5-bromo-4-chloroindol-3-yl)-phosphate (U-3'BCIP) is described, and preliminary kinetic studies indicate that this compound may have practical use for assaying RNase A activity both in vitro and in vivo.
A critical evaluation of the predicted and X-ray structures of α-Lactalbumin
TL;DR: Acharyaet et al. as discussed by the authors compared the three-dimensional structure of baboon α-Lactalbumin derived from X-ray crystallography with the experimentally determined structure except in the flexible C-terminal region.
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Mechanism of action of thrombin on fibrinogen. On the role of the A chain of bovine thrombin in specificity and in differentiating between thrombin and trypsin.
TL;DR: It is concluded that the B chain retains a sufficient number of interacting groups to refold correctly, and it is suggested that prothrombin might fold in localized domains with only weak interactions between domains.
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A new approach to empirical intermolecular and conformational potential energy functions. I. Description of model and derivation of parameters.
TL;DR: The results indicate that both intramolecular and intermolecular interaction energies can be treated with the same set of parameters and there is no need for special hydrogen bonding functions to account for the directionality and energetics of hydrogen bonding.
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