Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
Conformational energy calculations of enzyme-substrate complexes of lysozyme. I. Energy minimization of monosaccharide and oligosaccharide inhibitors and substrates of lysozyme.
TL;DR: The most stable conformations of β‐N‐acetylmuramic acid (NAM) were determined from the study of the low‐energy conformationsOf NAG, the O—C—C′ plane was found to be normal to the mean plane of the pyranosyl ring.
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Helix-coil stability constants for the naturally occurring amino acids in water. XII. Asparagine parameters from random poly(hydroxybutylglutamine-co-L-asparagine)
TL;DR: The synthesis and characterization of water‐soluble randomCopolymers containing L‐asparagine with N5‐(4‐hydroxybutyl)‐L‐glutamine, and the thermally induced helix‐coil transitions of these copolymers in water, are described and indicate that asparagine destabilizes helical sequences at all temperatures in the range 0–60°C.
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A possible folding pathway of bovine pancreatic RNase
TL;DR: The pathway deduced from the contact map agrees with experimental information on intermediates detected in the thermal unfolding of RNase and in immunochemical studies on the formation of stable antigenic sites when deduced RNase is oxidized with glutathione.
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Further evidence for the absence of polyproline II stretch in the XAO peptide.
Joanna Makowska,Joanna Makowska,Sylwia Rodziewicz-Motowidło,Sylwia Rodziewicz-Motowidło,Katarzyna Bagińska,Mariusz Makowski,Mariusz Makowski,Jorge A. Vila,Jorge A. Vila,Adam Liwo,Lech Chmurzyński,Harold A. Scheraga +11 more
TL;DR: It is demonstrated that the temperature dependence of the (3)J(HNHalpha) coupling constants of the alanine residues can be explained qualitatively in terms of Boltzmann averaging over all local conformational states; therefore, this temperature dependence proves that a conformational transition does not occur.
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