Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
Molecular Theory of the Helix–Coil Transition in Polyamino Acids. III. Evaluation and Analysis of s and σ for Polyglycine and Poly‐l‐alanine in Water
TL;DR: In this paper, the Zimm-Bragg parameters s and σ for the helix-coil transition in polyglycine and polyl-alanine were calculated in terms of molecular quantities.
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Structure of a hydrophobically collapsed intermediate on the conformational folding pathway of ribonuclease A probed by hydrogen-deuterium exchange.
TL;DR: The observations are consistent with I phi being a molten-globule-like intermediate, which implies that a slower refolding rate allows for a higher cooperativity between the different structural elements of the protein, resulting in the formation of more stable (native-like) intermediates (as in Ii) during the folding process.
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The nature of the initial step in the conformational folding of disulphide-intact ribonuclease A.
TL;DR: The kinetic data indicate that the conformational folding of ribonuclease A proceeds through the formation of a hydrophobically collapsed intermediate with properties similar to those of equilibrium molten-globules.
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Calculation of protein conformation as an assembly of stable overlapping segments: application to bovine pancreatic trypsin inhibitor.
TL;DR: The earlier buildup procedure was modified by taking account of a statistical analysis of known amino acid sequences that indicates that there is nonrandom pairing of amino acid residues in short segments along the chain, and by carrying out energy minimization on only these segments and on the whole chain.
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