Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
Chat about Author
Papers
Identification of two anti-parallel β-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance
TL;DR: Solution NMR data are described that provide evidence that the solution conformation of murine EGF includes an anti-parallel beta-sheet structure involving residues S2-P4, V19-I23, and S28-N32; a small anti-Parallel Beta-sheet involving residues Y37-S38 and T44-R45; and a multiple-bend structure for residues C6-C14 that is disulfide bonded to the V19.
67
Interactions between an alpha-helix and a beta-sheet. Energetics of alpha/beta packing in proteins.
TL;DR: In this article, a CH3CO-(L-Ala)16-NHCH3 alpha-helix interacting with five-stranded beta-sheets composed of CH3Co(L-Val)6-NH CH3 chains was investigated.
67
Optimization of the UNRES Force Field by Hierarchical Design of the Potential-Energy Landscape. 2. Off-Lattice Tests of the Method with Single Proteins
TL;DR: The application of the recently proposed method of hierarchical optimization of the protein energy landscape to optimize the off-lattice united-residue (UNRES) force field using single training proteins confirmed that a proper design of the structural hierarchy is of crucial importance to the foldability with the resulting potential-energy function.
66
Regeneration of bovine pancreatic ribonuclease A. 2. Kinetics of regeneration
TL;DR: The analysis reveals that RNase A regenerates with oxidized and reduced dithiothreitol (DTTox and DTTred, respectively) through a rearrangement pathway involving one or more three-disulfide species; i.e., multiple pathways could be involved.
66