Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen.
TL;DR: There is a chain reversal within residues Asp(7)-Arg(16) such that Phe (8) is brought close to the Arg(16)-Gly(17) peptide bond in the thrombin-peptide complex, as indicated by transferred NOEs between the aromatic ring protons of Phe(8) and the C alpha H protons
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Protein structure prediction using a combination of sequence homology and global energy minimization I. Global energy minimization of surface loops
TL;DR: In this article, the ECEPP potential function has been modified to allow more accurate representations of hydrogen bond interactions and intrinsic torsional energies, and a computationally efficient representation of hydration free energy has been introduced.
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The effect of neighboring charges on the helix forming ability of charged amino acids in proteins.
TL;DR: It has been found that the fraction of glutamic acid residues which are helical in proteins is larger than might be expected from the experimentally determined value of the helical stability constants ofglutamic acid.
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A computer modeling postulated mechanism for angiotensin II receptor activation.
TL;DR: The angiotensin II receptor of the AT1-type has been modeled starting from the experimentally determined three-dimensional structure of bacteriorhodopsin as the template, and a plausible mechanism of receptor activation is proposed.
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Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. II. Characterization of the Host Polymers and Application of the Host-Guest Technique to Random Poly(hydroxypropylglutamine-co-hydroxybutylglutamine)
P. H. von Dreele,N. Lotan,V. S. Ananthanarayanan,R. H. Andreatta,D. Poland,Harold A. Scheraga +5 more
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