Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
Origin of the right-handed twist of beta-sheets of poly(LVal) chains.
Kuo-Chen Chou,Harold A. Scheraga +1 more
TL;DR: The energies of three- and five-chain antiparallel and parallel beta-sheets were minimized, and the minimum-energy structures had a considerable right-handed twist, as observed in globular proteins.
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Atomically detailed folding simulation of the B domain of staphylococcal protein A from random structures
TL;DR: These results show that the protein-folding problem can be solved at the atomic detail level by an ab initio procedure, starting from random conformations, with no knowledge except the amino acid sequence.
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Calculation of protein conformation by global optimization of a potential energy function.
TL;DR: The results support the thermodynamic hypothesis that protein structure can be computed solely by global optimization of a potential energy function for a given amino acid sequence.
89
Intramolecular versus intermolecular disulfide bonds in prion proteins.
TL;DR: Evidence is provided that PrPSc can induce the conversion of the oxidized, disulfide-intact form of the monomeric cellular prion protein to its protease-resistant form without the temporary breakage and subsequent re-formation of the disulfides bonds in cell-free reactions.
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