Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
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Papers
Ribonucleases as Models for Understanding Protein Folding
Harold A. Scheraga
- 01 Jan 2011
TL;DR: The experimental studies were carried out to obtain information about the three-dimensional structure and folding/unfolding pathways of bovine pancreatic ribonuclease A and three of its structural homologs, ribonuclelease B, frog onconase, and bovines angiogenin.
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New Insights into Folding, Misfolding and Nonfolding Dynamics of a WW Domain
Khatuna Kachlishvili,Anatolii Korneev,Luka Maisuradze,Luka Maisuradze,Jiaojiao Liu,Harold A. Scheraga,Alexander Molochkov,Patrick Senet,Patrick Senet,Antti J. Niemi,Gia G. Maisuradze +10 more
TL;DR: It is demonstrated that the replacement of Leu26 by Asp26 or Trp26 (in ~15% of the folding trajectories) can alter the folding scenario from three-state folding, a major folding scenario for the FBP28 WW domain and its mutants, toward two-state or downhill folding at temperatures below the melting point.
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Identification of GATC- and CCGG-recognizing Type II REases and their putative specificity-determining positions using Scan2S--a novel motif scan algorithm with optional secondary structure constraints.
TL;DR: Novel REase sequence motifs are defined, which extend beyond the PD‐(D/E)XK hallmark, and incorporate secondary structure information, and are candidates for specificity re‐engineering.
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Characterizing the unstructured intermediates in oxidative folding.
TL;DR: It is shown here that there is a 10-fold increase in the propensity of the unfolded reduced forms of RNase A to form the native set of disulfides directly, compared to the propensity under strongly denaturing conditions.
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