Harold A. Scheraga
Cornell University
1160 Papers
25.6K Citations
Harold A. Scheraga is an academic researcher from Cornell University. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 120, co-authored 1152 publications. Previous affiliations of Harold A. Scheraga include University of Gdańsk & National University of San Luis.
Chat about Author
Papers
Oxidative folding pathway of onconase, a ribonuclease homologue: insight into oxidative folding mechanisms from a study of two homologues.
TL;DR: Compared to RNase A, ONC utilizes more efficient interactions along the oxidative folding pathway to adopt its native fold more rapidly, and the effects of temperature on the oxidative fold pathway have been examined.
Ab initio structure prediction of two α‐helical oligomers with a multiple‐chain united‐residue force field and global search
TL;DR: The native structures of two oligomeric proteins from the CASP3 exercise, the retro‐GCN4 leucine zipper and the synthetic domain‐swapped dimer, were identified as the lowest‐energy families resulting from the search of the proteins when rotational symmetry was imposed.
20
Preventing fibril formation of a protein by selective mutation.
Gia G. Maisuradze,Jordi Medina,Khatuna Kachlishvili,Paweł Krupa,Paweł Krupa,Magdalena A. Mozolewska,Magdalena A. Mozolewska,Pau Martin-Malpartida,Luka Maisuradze,Maria J. Macias,Harold A. Scheraga +10 more
TL;DR: Results indicate that formation of hairpins connecting two antiparallel β-strands determines overall folding, which may provide an understanding of protein folding intermediates in general and lead to a procedure for their prevention.
20