Harit Panda
Tohoku University
6 Papers
Harit Panda is an academic researcher from Tohoku University. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 2, co-authored 3 publications.
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Papers
Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors
Makiko Hayashi,Ayumi Kuga,Mikiko Suzuki,Harit Panda,Hiroshi Kitamura,Hozumi Motohashi,Masayuki Yamamoto +6 more
TL;DR: It is demonstrated that microenvironmental Nrf2 activation suppresses the progression of malignant NRF2-activated tumors and that Nrf 2 activation in immune cells at least partially contributes to these suppressive effects.
Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease Milieu
TL;DR: The multifarious roles of the KEAP1–NRF2 system in various types of cells, especially focusing on cancer and inflammatory diseases are introduced and NRF2 inducers have been utilized for the treatment of inflammatory diseases.
Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.
Harit Panda,Nadine Keleku-Lukwete,Ayumi Kuga,Nobuo Fuke,Hiroyuki Suganuma,Mikiko Suzuki,Masayuki Yamamoto +6 more
TL;DR: It is demonstrated that dietary supplementation with SFN relieves SCD symptoms by inducing Nrf2 and support the contention that SFN is a potential drug for the long-term treatment of children with SCD.
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Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice
Nadine Keleku-Lukwete,Mikiko Suzuki,Harit Panda,Akihito Otsuki,Fumiki Katsuoka,Ritsumi Saito,Daisuke Saigusa,Akira Uruno,Masayuki Yamamoto +8 more
TL;DR: Vascular function in SCD::Keap1F/F::Tie1-Cre mice was significantly improved, with a 50% decrease in vascular leakage and low expression of the adhesion molecules Vcam1 and P-selectin.
The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
Ayumi Kuga,Kouhei Tsuchida,Harit Panda,Makoto Horiuchi,Akihito Otsuki,Keiko Taguchi,Fumiki Katsuoka,Mikiko Suzuki,Masayuki Yamamoto +8 more
TL;DR: Results indicate that the β-TrCP-mediated pathway cooperates with the Keap1- mediated pathway to regulate Nrf2 activity, which is apparent when the KeAP1-mediated pathways is profoundly suppressed.