Harald von Boehmer
Harvard University
199 Papers
4.8K Citations
Harald von Boehmer is an academic researcher from Harvard University. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 87, co-authored 199 publications. Previous affiliations of Harald von Boehmer include Polish Academy of Sciences & French Institute of Health and Medical Research.
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Papers
DNA methylation controls Foxp3 gene expression.
Julia K. Polansky,Karsten Kretschmer,Karsten Kretschmer,Jennifer Freyer,Stefan Floess,Annette I. Garbe,Annette I. Garbe,Udo Baron,Sven Olek,Alf Hamann,Harald von Boehmer,Jochen Huehn +11 more
TL;DR: It is reported that inhibition of DNA methylation by azacytidine, even in absence of exogenous TGF‐β, not only promoted de novo induction of Foxp3 expression during priming, but also conferred stability of Fox p3 expression upon restimulation.
809
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Alexander Marson,Karsten Kretschmer,Garrett M. Frampton,Elizabeth S Jacobsen,Julia K. Polansky,Kenzie D MacIsaac,Stuart S. Levine,Ernest Fraenkel,Harald von Boehmer,Richard A. Young +9 more
TL;DR: The predominant, although not exclusive, effect of Foxp3 occupancy is to suppress the activation of target genes on T-cell stimulation, which appears to be crucial for the normal function of Treg cells.
768
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
Hung Sia Teh,Hung Sia Teh,Hung Sia Teh,Pawel Kisielow,Pawel Kisielow,Pawel Kisielow,Bernadette Scott,H Kishi,Yasushi Uematsu,Horst Blüthmann,Harald von Boehmer +10 more
TL;DR: The results indicate that the specific interaction of the T-cell receptor on immature thymocyte with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4-8– or CD4–8+ mature T cells.
692
Frontline: Neuropilin-1: a surface marker of regulatory T cells
Dunja Bruder,Michael Probst-Kepper,Astrid M. Westendorf,Robert Geffers,Stefan Beissert,Karin Loser,Harald von Boehmer,Jan Buer,Wiebke Hansen +8 more
TL;DR: In this paper, the authors identified neuropilin-1 (Nrp1) as a specific surface marker for CD4+CD25+ Treg cells, which constitutes a useful surface marker to distinguish T cells from both naive and recently activated non-regulatory T cells.
496
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
TL;DR: The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T -ALL pathogenesis than previously suspected.
490