Harald John
Ludwig Maximilian University of Munich
107 Papers
744 Citations
Harald John is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chemistry & Mass spectrometry. The author has an hindex of 27, co-authored 94 publications. Previous affiliations of Harald John include University of Göttingen.
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Papers
Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network.
Harald John,Marcel J. van der Schans,Marianne Koller,Helma E.T. Spruit,Franz Worek,Horst Thiermann,Daan Noort +6 more
TL;DR: Experimental results provided unambiguous evidence for a systemic intoxication and were the first proving the use of sarin in the ongoing bellicose conflict, highlighting the requirement for qualified and specialized analytical laboratories to face repeated violation of the Chemical Weapons Convention.
Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography–mass spectrometry
TL;DR: Procedures based on LC–MS techniques for quantitative determination of peptides are reviewed using numerous examples from the literature, complemented by experiments and results from the laboratory.
167
A role for solvents in the toxicity of agricultural organophosphorus pesticides
Michael Eddleston,Jonathan M. Street,Ian Self,Adrian Thompson,Tim King,Nicola Williams,Gregorio Naredo,Kosala N. Dissanayake,Ly-Mee Yu,Franz Worek,Harald John,Sionagh Smith,Horst Thiermann,John Harris,R Eddie Clutton +14 more
TL;DR: Results indicate that solvents play a crucial role in dimethoate toxicity and reformulation of OP insecticides to ensure that the agricultural product has lower mammalian toxicity could result in fewer deaths after suicidal ingestion and rapidly reduce global suicide rates.
113
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning
TL;DR: LC-MS-MS detection of phosphylated peptides generated from inhibited circulating serum butyrylcholinesterase by valuable proteomics techniques enables proof of intoxication on the molecular level, and a comprehensive overview on the status quo of LC- MS-based OPC analysis is given.
112
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.
TL;DR: Novel adducts of human serum albumin (HSA) are detected and identified by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and exhibits potential as a verification tool for high-dose exposure.
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