37 Papers
65 Citations
Hao Yu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 14, co-authored 27 publications.
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Papers
Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas
TL;DR: The proteins and functional pathway identified in the current study represent attractive targets for degradation of environmental toxic compounds.
Structural basis for the recognition of sulfur in phosphorothioated DNA
Guang Liu,Wencheng Fu,Zhenyi Zhang,Yao He,Hao Yu,Yuli Wang,Xiao-Lei Wang,Yi-Lei Zhao,Zixin Deng,Geng Wu,Xinyi He +10 more
TL;DR: Insight into sulfur recognition is provided by solving the crystal structure of the PT-DNA bound sulfur-binding domain (SBD) from ScoMcrA and it is shown that SBD homologs are widely spread among prokaryotes.
Molybdenum-Containing Nicotine Hydroxylase Genes in a Nicotine Degradation Pathway That Is a Variant of the Pyridine and Pyrrolidine Pathways
TL;DR: It is demonstrated that VppA is a two-component molybdenum-containing hydroxylase, which converts nicotine to 6-hydroxynicotine in the strain SJY1.
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Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16.
TL;DR: The investigation on the catalytic mechanism of a flavoprotein pyridine-ring β-position hydroxylase provides useful information for the biosynthesis of pyragine derivatives.
29
Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex.
Hongliang Qian,Hao Yu,Peifei Li,E Zhu,Qingqing Yao,Cui Tai,Zixin Deng,Kenn Gerdes,Xinyi He,Jianhua Gan,Hong-Yu Ou +10 more
TL;DR: The crystal structure of DNA-bound KacAT complex is presented and an experimentally supported molecular model proposing that the KacT:KacA ratio controls kacAT transcription by conditional cooperativity yields a profound understanding of how transcription GNAT–RHH pairs are regulated.