Hao Yang

TL;DR: This work covalently link an alkyne-substituted dirhodium catalyst to a prolyl oligopeptidase containing a genetically encoded L-4-azidophenylalanine residue to create an ArM that catalyses olefin cyclopropanation that reduces the formation of byproducts, including those resulting from the reaction of Dirhodium–carbene intermediates with water.

TL;DR: In this paper, a short and sustainable synthesis of molnupiravir (MK-4482) from simple raw materials that would minimize the time needed to manufacture and supply moln upiravirus was proposed, enabled by the invention of a novel biocatalytic cascade featuring an engineered ribosyl-1kinase and uridine phosphorylase.

TL;DR: A bioconjugation strategy for modification of native peptides relying on high site selectivity conveyed by enzymes, and enzymatic activity on a range of bioactive peptides, suggesting that biocatalytic approaches may help in the development of potential peptide-based therapeutics or probes.

TL;DR: This study provides the first experimental insight into how selectivity might be achieved for different G-quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy.