Hao Wang
Scripps Research Institute
13 Papers
30 Citations
Hao Wang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Apolipoprotein E & Lipid raft. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Hao Wang include Scripps Health & Shenzhen University.
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Papers
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.
TL;DR: Superresolution imaging in the mouse brain is used to show that apoE utilizes astrocyte-derived cholesterol to specifically traffic neuronal amyloid precursor protein in and out of lipid clusters, where it interacts with β- and γ-secretases to generate Aβ-peptide.
Studies on the mechanism of general anesthesia.
TL;DR: A membrane-mediated target of inhaled anesthesia is established and PA helps set thresholds of anesthetic sensitivity in vivo and is suggested to be an important consideration for other proteins of which direct binding of anesthetics has yet to explain conserved sensitivity.
182
Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels.
TL;DR: Palmitate-mediated localization of PLD2 emerges as a central control mechanism of TREK-1 responding to mechanical force and anesthetic action, a putative model for excitatory and inhibitory mechano-effectors and anesthesia sensitive ion channels in a biological context.
35
Regulation of amyloid processing in neurons by astrocyte-derived cholesterol
TL;DR: It is found that targeted deletion of astrocyte cholesterol synthesis robustly reduces amyloid and tau burden in a mouse model of AD and prevents Alzheimer’s-associated amyloids pathology in mice.
29
Hydroxychloroquine: mechanism of action inhibiting SARS-CoV2 entry
TL;DR: It is concluded HCQ is an anesthetic-like compound that disrupts GM1 lipid rafts similar to general anesthetics, which likely decreases viral clustering at both endocytic and putative PIP2 entry points.