Hao Guo
Xuzhou Medical College
16 Papers
70 Citations
Hao Guo is an academic researcher from Xuzhou Medical College. The author has contributed to research in topics: Streptozotocin & Kidney. The author has an hindex of 10, co-authored 15 publications.
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Papers
Ibuprofen Attenuates Cardiac Fibrosis in Streptozotocin-Induced Diabetic Rats
Weili Qiao,Cheng Wang,Bing Chen,Fan Zhang,Yao-Wu Liu,Qian Lu,Hao Guo,Changdong Yan,Hong Sun,Gang Hu,Xiaoxing Yin +10 more
TL;DR: Ibuprofen could ameliorate the cardiac fibrosis in diabetic rats by reduction of theACE/AngII/AT1-R axis and enhancement of the ACE2/Ang(1-7)/Mas-Raxis axis, leading to a decrease in TGF-β1 and mTOR.
147
Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.
Yao-Wu Liu,Xia Zhu,Liang Zhang,Qian Lu,Jian-Yun Wang,Fan Zhang,Hao Guo,Jiale Yin,Xiaoxing Yin +8 more
TL;DR: Mangiferin can remarkably ameliorate DN in rats through inhibiting the AGEs/RAGE aix and oxidative stress damage, and Glo-1 may be a target for mangiferin action.
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Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats.
TL;DR: It is demonstrated that mangiferin prevents the renal glomerulus fibrosis of diabetic rats, which is realized through the suppression of osteopontin overproduction and inflammation likely via inactivation of NF‐кB.
70
LFG-500, a newly synthesized flavonoid, attenuates lipopolysaccharide-induced acute lung injury and inflammation in mice.
Chenglin Li,Dan Yang,Xin Cao,Fan Wang,Haijing Jiang,Hao Guo,Lei Du,Qinglong Guo,Xiaoxing Yin +8 more
TL;DR: In vivo protective effect of LFG-500 on the amelioration of lipopolysaccharide (LPS)-induced ALI and inflammation was detected and elucidation of the mechanism revealed that p38 and JNK MAPK pathways were involved in the anti-inflammation effect of
50
Extracts of black bean peel and pomegranate peel ameliorate oxidative stress‑induced hyperglycemia in mice
TL;DR: PE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage; this finding may be useful in the prevention and treatment of DM.