11 Papers
16 Citations
Hao Geng is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Prostate cancer & Biology. The author has an hindex of 8, co-authored 11 publications.
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Papers
HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia
Hao Geng,Christopher T. Harvey,Janét Pittsenbarger,Qiong Liu,Tomasz M. Beer,Changhui Xue,David Z. Qian +6 more
TL;DR: The novel biological relationship between HDAC4 and HIF1α presented here suggests a potential role for the deacetylase enzyme in regulating HIF-1 cancer cell response to hypoxia and presents a more specific molecular target of inhibition.
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HIF1α Protein Stability Is Increased by Acetylation at Lysine 709
Hao Geng,Qiong Liu,Changhui Xue,Larry L. David,Tomasz M. Beer,George Thomas,Mu Shui Dai,David Z. Qian +7 more
TL;DR: A novel biological consequence upon HIF1α-p300 interaction is demonstrated, in which Hif1α can be stabilized by p300 via Lys-709 acetylation, which increases the protein stability and decreases polyubiquitination in both normoxia and hypoxia.
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Malate dehydrogenase 2 confers docetaxel resistance via regulations of JNK signaling and oxidative metabolism.
Qiong Liu,Christopher T. Harvey,Hao Geng,Changhui Xue,Vivian Chen,Tomasz M. Beer,David Z. Qian +6 more
TL;DR: Novel mechanistic understandings in cancer cell chemotherapeutic sensitivity and resistance can optimize treatment and improve patient outcome in prostate cancer therapeutics.
A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma
Natsuko Suwaki,Elsa Vanhecke,Katelyn M. Atkins,Manuela Graf,Katherine Swabey,Paul H. Huang,Peter Schraml,Holger Moch,Amy Mulick Cassidy,Daniel Brewer,Bissan Al-Lazikani,Paul Workman,J. De-Bono,Stan B. Kaye,James Larkin,Martin Gore,Charles L. Sawyers,Peter S. Nelson,Tomasz M. Beer,Hao Geng,Lina Gao,David Z. Qian,Joshi J. Alumkal,Gary Thomas,George Thomas +24 more
TL;DR: Signaling through the VHL-PTP1B-Src pathway in renal cell carcinomas may determine sensitivity to Src inhibitors and provide a basis for treatment planning, and the markers for an activated Src pathway discerned could in theory be assessed in any solid cancer.
Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy.
Hao Geng,Changhui Xue,Janet Mendonca,Xiao Xin Sun,Qiong Liu,Patrick N. Reardon,Yingxiao Chen,Kendrick Qian,Vivian Hua,Alice P. Chen,Freddy Pan,Julia Yuan,Sang Dang,Tomasz M. Beer,Mu Shui Dai,Sushant Kachhap,David Z. Qian +16 more
TL;DR: It is shown that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalUTamide.
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