Radiomics converts medical images into mineable data via a high-throughput extraction of quantitative features used for clinical decision support. However, these radiomic features are susceptible to variation across scanners, acquisition protocols, and reconstruction settings. Various investigations have assessed the reproducibility and validation of radiomic features across these discrepancies. In this narrative review, we combine systematic keyword searches with prior domain knowledge to discuss various harmonization solutions to make the radiomic features more reproducible across various scanners and protocol settings. Different harmonization solutions are discussed and divided into two main categories: image domain and feature domain. The image domain category comprises methods such as the standardization of image acquisition, post-processing of raw sensor-level image data, data augmentation techniques, and style transfer. The feature domain category consists of methods such as the identification of reproducible features and normalization techniques such as statistical normalization, intensity harmonization, ComBat and its derivatives, and normalization using deep learning. We also reflect upon the importance of deep learning solutions for addressing variability across multi-centric radiomic studies especially using generative adversarial networks (GANs), neural style transfer (NST) techniques, or a combination of both. We cover a broader range of methods especially GANs and NST methods in more detail than previous reviews.

Making Radiomics More Reproducible across Scanner and Imaging Protocol Variations: A Review of Harmonization Methods

The emergence of Chat Generative Pre-trained Transformer (ChatGPT), a chatbot developed by OpenAI, has garnered interest in the application of generative artificial intelligence (AI) models in the medical field. This review summarizes different generative AI models and their potential applications in the field of medicine and explores the evolving landscape of Generative Adversarial Networks and diffusion models since the introduction of generative AI models. These models have made valuable contributions to the field of radiology. Furthermore, this review also explores the significance of synthetic data in addressing privacy concerns and augmenting data diversity and quality within the medical domain, in addition to emphasizing the role of inversion in the investigation of generative models and outlining an approach to replicate this process. We provide an overview of Large Language Models, such as GPTs and bidirectional encoder representations (BERTs), that focus on prominent representatives and discuss recent initiatives involving language-vision models in radiology, including innovative large language and vision assistant for biomedicine (LLaVa-Med), to illustrate their practical application. This comprehensive review offers insights into the wide-ranging applications of generative AI models in clinical research and emphasizes their transformative potential.

Updated Primer on Generative Artificial Intelligence and Large Language Models in Medical Imaging for Medical Professionals

With the ever-increasing use of computed tomography (CT), concerns about its radiation dose have become a significant public issue. To address the need for radiation dose reduction, CT denoising methods have been widely investigated and applied in low-dose CT images. Numerous noise reduction algorithms have emerged, such as iterative reconstruction and most recently, deep learning (DL)-based approaches. Given the rapid advancements in Artificial Intelligence techniques, we recognize the need for a comprehensive review that emphasizes the most recently developed methods. Hence, we have performed a thorough analysis of existing literature to provide such a review. Beyond directly comparing the performance, we focus on pivotal aspects, including model training, validation, testing, generalizability, vulnerability, and evaluation methods. This review is expected to raise awareness of the various facets involved in CT image denoising and the specific challenges in developing DL-based models.

CT image denoising methods for image quality improvement and radiation dose reduction.

OBJECTIVES
To investigate the improvement of two denoising models with different learning targets (Dir and Res) of generative adversarial network (GAN) on image quality and lung nodule detectability in chest low-dose CT (LDCT).


METHODS
In training phase, by using LDCT images simulated from standard dose CT (SDCT) of 200 participants, Dir model was trained targeting SDCT images, while Res model targeting the residual between SDCT and LDCT images. In testing phase, a phantom and 95 chest LDCT, exclusively with training data, were included for evaluation of imaging quality and pulmonary nodules detectability.


RESULTS
For phantom images, structural similarity, peak signal-to-noise ratio of both Res and Dir models were higher than that of LDCT. Standard deviation of Res model was the lowest. For patient images, image noise and quality of both two models, were better than that of LDCT. Artifacts of Res model was less than that of LDCT. The diagnostic sensitivity of lung nodule by two readers for LDCT, Res and Dir model, were 72/77%, 79/83% and 72/79% respectively.


CONCLUSION
Two GAN denoising models, including Res and Dir trained with different targets, could effectively reduce image noise of chest LDCT. The image quality evaluation scoring and nodule detectability of Res denoising model was better than that of Dir denoising model and that of hybrid IR images.


ADVANCES IN KNOWLEDGE
The GAN-trained model, which learned the residual between SDCT and LDCT images, reduced image noise and increased the lung nodule detectability by radiologists on chest LDCT. This demonstrates the potential for clinical benefit.

Improving image quality and lung nodule detection for low-dose chest CT by using generative adversarial network reconstruction.

Objective We aimed to evaluate the reporting quality of research articles that applied deep learning to medical imaging. Using the Checklist for Artificial Intelligence in Medical Imaging (CLAIM) guidelines and a journal with prominence in Asia as a sample, we intended to provide an insight into reporting quality in the Asian region and establish a journal-specific audit. Materials and Methods A total of 38 articles published in the Korean Journal of Radiology between June 2018 and January 2023 were analyzed. The analysis included calculating the percentage of studies that adhered to each CLAIM item and identifying items that were met by ≤ 50% of the studies. The article review was initially conducted independently by two reviewers, and the consensus results were used for the final analysis. We also compared adherence rates to CLAIM before and after December 2020. Results Of the 42 items in the CLAIM guidelines, 12 items (29%) were satisfied by ≤ 50% of the included articles. None of the studies reported handling missing data (item #13). Only one study respectively presented the use of de-identification methods (#12), intended sample size (#19), robustness or sensitivity analysis (#30), and full study protocol (#41). Of the studies, 35% reported the selection of data subsets (#10), 40% reported registration information (#40), and 50% measured inter and intrarater variability (#18). No significant changes were observed in the rates of adherence to these 12 items before and after December 2020. Conclusion The reporting quality of artificial intelligence studies according to CLAIM guidelines, in our study sample, showed room for improvement. We recommend that the authors and reviewers have a solid understanding of the relevant reporting guidelines and ensure that the essential elements are adequately reported when writing and reviewing the manuscripts for publication.

Reporting Quality of Research Studies on AI Applications in Medical Images According to the CLAIM Guidelines in a Radiology Journal With a Strong Prominence in Asia

Objective To investigate the image quality of ultralow-dose CT (ULDCT) of the chest reconstructed using a cycle-consistent generative adversarial network (CycleGAN)-based deep learning method in the evaluation of pulmonary tuberculosis. Materials and methods Between June 2019 and November 2019, 103 patients (mean age, 40.8 ± 13.6 years; 61 men and 42 women) with pulmonary tuberculosis were prospectively enrolled to undergo standard-dose CT (120 kVp with automated exposure control), followed immediately by ULDCT (80 kVp and 10 mAs). The images of the two successive scans were used to train the CycleGAN framework for image-to-image translation. The denoising efficacy of the CycleGAN algorithm was compared with that of hybrid and model-based iterative reconstruction. Repeated-measures analysis of variance and Wilcoxon signed-rank test were performed to compare the objective measurements and the subjective image quality scores, respectively. Results With the optimized CycleGAN denoising model, using the ULDCT images as input, the peak signal-to-noise ratio and structural similarity index improved by 2.0 dB and 0.21, respectively. The CycleGAN-generated denoised ULDCT images typically provided satisfactory image quality for optimal visibility of anatomic structures and pathological findings, with a lower level of image noise (mean ± standard deviation [SD], 19.5 ± 3.0 Hounsfield unit [HU]) than that of the hybrid (66.3 ± 10.5 HU, p 0.908). The CycleGAN-generated images showed the highest contrast-to-noise ratios for the pulmonary lesions, followed by the model-based and hybrid iterative reconstruction. The mean effective radiation dose of ULDCT was 0.12 mSv with a mean 93.9% reduction compared to standard-dose CT. Conclusion The optimized CycleGAN technique may allow the synthesis of diagnostically acceptable images from ULDCT of the chest for the evaluation of pulmonary tuberculosis.

/pdf/cycle-consistent-generative-adversarial-network-effect-on-44sesbp2ig.pdf

Cycle-Consistent Generative Adversarial Network: Effect on Radiation Dose Reduction and Image Quality Improvement in Ultralow-Dose CT for Evaluation of Pulmonary Tuberculosis.

Due to repeated examinations of lung nodules by Standard Dose Computed Tomography (SDCT), patients suffer from an increased risk of further cancer deterioration caused by the accumulated X-ray dose. Although radiologist have attempted using Ultra-low dose CT images instead of SDCT for diagnosis, the reduction of CT dose decreases the final reconstructed image quality and seriously hinders diagnosis. To compensate for the reduced image quality, we presents a novel noise reduction approach, conditional Denoising Diffusion Probabilistic Model (c-DDPM), by exploiting the advantages of Diffusion Probabilistic Models (DDPM). c-DDPM applies a 2.5D feature fusion strategy to account for CT spatial details, and constrains the denoising procession, by combining the loss function l2 and lssim. We evaluate c-DDPM and a state-of-the-art method CycleGAN, the commercial IMR method and iDose on an actual patients dataset with a total of 170 patients. Objective assessment shows that c-DDPM can suppress the isolated artifacts and generate more compelling ULDCT images with PSNR (35.19±0.73) and SSIM (0.85±0.03). The subjective evaluation performed by radiologists also demonstrates that our approach can effectively improve perceptual image quality, achieving an overall image quality score of 4/5 or above in 88.4% of cases and an image noise score of 4/5 or above in 100% of the cases. Finally, we provides comprehensive empirical evidence showing that in the lung nodule detection task, ULDCT images denoised through c-DDPM my be detected 11% more valid nodules than of CycleGAN.

Ultra-low Dose CT Image Denoising based on Conditional Denoising Diffusion Probabilistic model

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Cycle-Consistent Generative Adversarial Network: Effect on Radiation Dose Reduction and Image Quality Improvement in Ultralow-Dose CT for Evaluation of Pulmonary Tuberculosis.

Ultra-low Dose CT Image Denoising based on Conditional Denoising Diffusion Probabilistic model